Korean J Gastrointest Endosc > Volume 28(1); 2004 > Article
Korean Journal of Gastrointestinal Endoscopy 2004;28(1): 29-33.
Helicobacter pylori 박멸과 장기간 Proton Pump 억제제 투여 후에 호전된 Menetrier씨 병 1예
전북대학교 의과대학 내과학교실
A Case of Improved Menetrier's Disease after the Eradication of the Helicobacter pylori and Long Term Treatment with Proton Pump Inhibitor
Kang-Hyu Lee, M.D., Na-Ri Lee, M.D., Jae-yong Kwak, M.D., Chang-yeol Yim, M.D. and Seung-Ok Lee, M.D.
Department of Internal Medicine, Chonbuk National University College of Medicine, Jeonju, Korea
Menetrier's disease is a protein losing hypertrophic gastropathy characterized by hypoproteinemia, and often is associated with the development of gastric cancer. Though the cause of Menetrier's disease has been unknown, the association with Helicobacter pylori was reported. A 30- year-old man was hospitalized for the evaluation of progressive dyspepsia for 2 years, hypoproteinemia, and recently aggravated epigastric pain with weight loss. Gastroscopy revealed prominent folds and multiple variable sized polypoid eminence in the body and antrum with positive CLO test. Histological findings revealed gastritis with erosions and foveolar hyperplasia. Any other diseases causing protein losing enteropathy were excluded. After the eradication of the H. pylori and long term treatment with proton pump inhibitor, clinical, endoscopic, and biochemical resolution ensued. Thus, we suggest that H. pylori eradication should be tried in patients with Menetrier's disease before invase treatment modalities such as surgical resection. (Korean J Gastrointest Endosc 2004; 28:29⁣33)
Key Words: Menetrier's disease, Helicobacter pylori
주요어: Menetrier씨 병, Helicobacter pylori
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