Korean J Gastrointest Endosc > Volume 30(6); 2005 > Article
Korean Journal of Gastrointestinal Endoscopy 2005;30(6): 330-335.
Rifampicin에 의한 위막성 대장염 1예
가톨릭대학교 의과대학 내과학교실, *임상병리학교실
A Case of Rifampicin-Associated Pseudomembranous Colitis
Hyung Keun Kim, M.D., Jin Woo Kim, M.D., Ok Ran Shin, M.D.*, Young Seok Cho, M.D., Sung Hyun Son, M.D., Sung Soo Kim, M.D., Hiun Suk Chae, M.D., Kwan Hyung Kim, M.D., Kyu Yong Choi, M.D. and In Sik Chung, M.D.
Departments of Internal Medicine and *Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Pseudomembranous colitis is a rare disease and is caused by abnormal overgrowth of toxin producing Clostridium difficile colonizing the large bowel of patients undergoing antibiotic therapy. Rifampicin is one of the first line anti- tuberculous agents, used worldwide. However, pseudomembranous colitis related to rifampicin usage is rare. We report a case of pseudomembranous colitis which developed in a 70-year-old male patient during the first line anti-tuberculous therapy including rifampicin. The patient was diagnosed with active pulmonary tuberculosis thirty days earlier. On admission, he suffered watery diarrhea and intermittent abdominal pain for 10 days. Sigmoidoscopic examination revealed diffusely scattered whitish to yellowish pseudomembrane with skipped areas or edematous hyperemic mucosa from rectum to descending colon, and histopathologic findings were consistent with pseudomembranous colitis with typical volcano-like exudate. Symptoms improved after excluding rifampicin and treatment with metronidazole. In patients with persistent diarrhea and abdominal pain receiving anti-tuberculous therapy including rifampicin, rifampicin-associated pseudomembranous colitis should be considered. (Korean J Gastrointest Endosc 2005;30:330⁣335)
Key Words: Pseudomembranous colitis, Rifampicin, Clostridium difficile
주요어: 위막성 대장염, Rifampicin, Clostridium difficile
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Related articles
Rifampin-induced Pseudomembranous Colitis with Rectosigmoid Sparing  2011 December;44(2)
Two Cases of Pyoderma Gangrenosum Associated with Recurrent Ulcerative Colitis  2010 November;41(5)
A Case of Cytomegalovirus and Pseudomembranous Colitis in an Immunocompetent Adult  2009 May;38(5)
Two Cases of Pneumatosis Coli Associated with Ischemic Colitis  2008 September;37(3)
A Case of Protein Loosing Enteropathy Associated with Pseudomembranous Colitis in a Patient with Peritonitis  2008 September;37(3)
Editorial Office
Korean Society of Gastrointestinal Endoscopy
#817, 156 Yanghwa-ro (LG Palace, Donggyo-dong), Mapo-gu, Seoul, 04050, Korea
TEL: +82-2-335-1552   FAX: +82-2-335-2690    E-mail: CE@gie.or.kr
Copyright © Korean Society of Gastrointestinal Endoscopy.                 Developed in M2PI
Close layer