Korean J Gastrointest Endosc > Volume 31(4); 2005 > Article
Korean Journal of Gastrointestinal Endoscopy 2005;31(4): 221-228.
소화성 궤양 출혈 환자에서 내시경적 주입치료 후 오메프라졸의 복합치료와 오메프라졸 단독 정맥 투여의 효과 비교
서울대학교병원 헬스케어시스템 강남센터, 헬스케어연구소, *분당서울대학교병원 내과, 서울의료원 내과
Comparison of Hemostatic Effects between a Combination Therapy Including Endoscopic Injection Therapy and Omeprazole and a Single Intravenous Omeprazole Therapy in Patients with Bleeding Peptic Ulcers
Seon Hee Lim, M.D., Nayoung Kim, M.D.* and Kye Heui Lee, M.D.
Seoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute, Seoul, *Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea

This study was performed to test whether there is some difference between combined endoscopic therapy with PPI infusion and intravenous PPI therapy alone.
A total of seventy-three high-risk patients with ulcer bleeding and non-bleeding visible vessels or fresh adherent clots resistant to irrigation were randomized to medical therapy [intravenous omeprazole therapy alone: 40 mg IV per day for 3∼5 days] or to endoscopic combination therapy [endoscopic epinephrine (1:10,000 in normal saline) or ethanol injection followed by intravenous omeprazole infusion].
Patients were similar at study entry. Ulcer bleeding recurred in two patients who received combined endoscopic therapy (2/35, 5.7%) while ulcer bleeding recurred in ten patients who received intravenous omeprazole alone (10/38, 26.3%) (p<0.05). Two patients (2/35, 5.7%) in the combined therapy group and five patients (5/38, 13.2%) in the omeprazole infusion alone group had surgery for intractable bleeding (p=0.281). One patient in each group died within the hospital stays (p=0.953).
The combination of endoscopic injection therapy with omeprazole infusion is superior to omeprazole infusion alone for preventing recurrent bleeding from ulcers with nonbleeding visible vessels or adherent clots. (Korean J Gastrointest Endosc 2005;31:221⁣228)
Key Words: Omeprazole, Peptic ulcer bleeding, Endoscopic injection therapy
주요어: 오메프라졸, 소화성 궤양 출혈, 내시경적 지혈 치료
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Related article
Comparison of Hemostatic Efficacy between Epinephrine Injection Alone and a Combined Therapy with Hemoclip for Bleeding Peptic Ulcers  2006 January;32(1)
Editorial Office
Korean Society of Gastrointestinal Endoscopy
#817, 156 Yanghwa-ro (LG Palace, Donggyo-dong), Mapo-gu, Seoul, 04050, Korea
TEL: +82-2-335-1552   FAX: +82-2-335-2690    E-mail: CE@gie.or.kr
Copyright © Korean Society of Gastrointestinal Endoscopy.                 Developed in M2PI
Close layer