Korean J Gastrointest Endosc > Volume 31(4); 2005 > Article
Korean Journal of Gastrointestinal Endoscopy 2005;31(4): 221-228.
소화성 궤양 출혈 환자에서 내시경적 주입치료 후 오메프라졸의 복합치료와 오메프라졸 단독 정맥 투여의 효과 비교
임선희·김나영*·이계희
서울대학교병원 헬스케어시스템 강남센터, 헬스케어연구소, *분당서울대학교병원 내과, 서울의료원 내과
Comparison of Hemostatic Effects between a Combination Therapy Including Endoscopic Injection Therapy and Omeprazole and a Single Intravenous Omeprazole Therapy in Patients with Bleeding Peptic Ulcers
Seon Hee Lim, M.D., Nayoung Kim, M.D.* and Kye Heui Lee, M.D.
Seoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute, Seoul, *Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea
Abstract

Background/Aims:
This study was performed to test whether there is some difference between combined endoscopic therapy with PPI infusion and intravenous PPI therapy alone.
Methods:
A total of seventy-three high-risk patients with ulcer bleeding and non-bleeding visible vessels or fresh adherent clots resistant to irrigation were randomized to medical therapy [intravenous omeprazole therapy alone: 40 mg IV per day for 3∼5 days] or to endoscopic combination therapy [endoscopic epinephrine (1:10,000 in normal saline) or ethanol injection followed by intravenous omeprazole infusion].
Results:
Patients were similar at study entry. Ulcer bleeding recurred in two patients who received combined endoscopic therapy (2/35, 5.7%) while ulcer bleeding recurred in ten patients who received intravenous omeprazole alone (10/38, 26.3%) (p<0.05). Two patients (2/35, 5.7%) in the combined therapy group and five patients (5/38, 13.2%) in the omeprazole infusion alone group had surgery for intractable bleeding (p=0.281). One patient in each group died within the hospital stays (p=0.953).
Conclusions:
The combination of endoscopic injection therapy with omeprazole infusion is superior to omeprazole infusion alone for preventing recurrent bleeding from ulcers with nonbleeding visible vessels or adherent clots. (Korean J Gastrointest Endosc 2005;31:221⁣228)
Key Words: Omeprazole, Peptic ulcer bleeding, Endoscopic injection therapy
주요어: 오메프라졸, 소화성 궤양 출혈, 내시경적 지혈 치료
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Comparison of Hemostatic Efficacy between Epinephrine Injection Alone and a Combined Therapy with Hemoclip for Bleeding Peptic Ulcers  2006 January;32(1)
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