Korean J Gastrointest Endosc > Volume 31(6); 2005 > Article
Korean Journal of Gastrointestinal Endoscopy 2005;31(6): 368-373.
대장내시경 전처치에서 4 L Polyethyleneglycol 단독투여와 45 mL Sodium Phosphate/2 L Polyethyleneglycol 병합투여의 비교: 전향적 무작위 대조 연구
고려대학교 의과대학 안암병원 내과
Comparison of 4 L of PEG Versus Combination of 2 L of PEG and 45 mL of Sodium Phosphate for Colonoscopy Colon Cleansing: A Prospective Randomized Trial
Jong Jin Hyun, M.D., Yoon Tae Jeen, M.D., Sang Hoon Park, M.D., Beom Jae Lee, M.D., Jong Hwan Choi, M.D., Hwang Rae Chun, M.D., Rok Son Choung, M.D., Yong Sik Kim, M.D., Hoon Jai Chun, M.D., Hong Sik Lee, M.D., Soon Ho Um, M.D., Sang Woo Lee, M.D., Jai Hy
Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea

Polyethyleneglycol (PEG) is safe but its large volume and bad taste reduces patients' compliance. Sodium phosphate (NaP) is a hyperosmotic agent and its small volume can increase patients' compliance but electrolyte imbalance is a problem. Therefore, we conducted a study to determine whether patients' compliance can be enhanced and electrolyte imbalance reduced by combining these two agents.
Forty-one admitted patients receiving colonoscopy at Korea University Hospital from June 28, 2004 to August 14, 2004 were randomly divided into two groups for colon cleansing with either PEG 4 L (n=21) or PEG 2 L plus NaP 45 mL (n=20). Patients were assessed for patient tolerance, quality of preparation, and changes of biochemical parameters.
Overall discomfort was statistically lower in the combination group, PEG 2 L plus NaP 45 mL (p=0.035). Although patients in the combination group reported less fullness (p=0.076) and nausea (p=0.087), the findings were not statistically significant. The quality of the preparation was comparable between the two groups (p=0.872). The phosphorus level in the combination group showed a statistically significant increase (0.58⁑0.46) after colon cleansing (p=0.020) but was not clinically significant.
The combination of NaP 45 mL and PEG 2 L showed less overall discomfort with comparable quality of preparation and without serious electrolyte abnormality compared to 4 L of PEG. Therefore, the combination of NaP 45 mL and PEG 2 L could be used as an alternative colonoscopic colon cleansing agent when patients have trouble taking 4 L of PEG alone. (Korean J Gastrointest Endosc 2005;31:368⁣373)
Key Words: Colonoscopy, Colon cleansing, Polyethyleneglycol, Sodium phosphate
주요어: 대장내시경, 전처치, Polyethyleneglycol, Sodium phosphate
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