Korean J Gastrointest Endosc > Volume 32(2); 2006 > Article
Korean Journal of Gastrointestinal Endoscopy 2006;32(2): 81-86.
상부위장관 표재성 종양에 대한 광역동 치료 효과
천영국·한대희·정인섭·유창범·조주영·김연수·이준성·이문성·심찬섭·김부성
순천향대학교 의과대학 내과학교실, 소화기연구소
Photodynamic Therapy for Superficial Gastrointestinal Tumors
Young Koog Cheon, M.D., Dae Hee Han, M.D., In Seop Jung, M.D., Chang Beom Ryu, M.D., Joo Young Cho, M.D., Yun Soo Kim, M.D., Joon Seong Lee, M.D., Moon Sung Lee, M.D., Chan Sup Shim, M.D. and Boo Sung Kim, M.D.
Department of Internal Medicine, Institute for Digestive Research, Soon Chun Hyang University College of Medicine, Seoul, Korea
Abstract

Background/Aims:
Although photodynamic therapy (PDT) has been used for the endoscopic treatment of digestive cancer, its curative efficacy remains uncertain. This study evaluated the curative role of PDT in superficial gastrointestinal cancer.
Methods:
Fifteen lesions in 14 patients with a histologically proven carcinoma (early esophageal cancer 6, early gastric cancer 8, ampulla of Vater cancer 1) were injected with an intravenous hematoporphyrin derivative (2 mg/kg), and PDT was performed 48 hours later. The response to treatment was assessed by gastroscopy with biopsies.
Results:
The median follow-up time was 273 days (42∼1,030 days). According to the TNM stage of endoscopic ultrasonography, there were 14 T1 cases and 1 T2 case. Complete remission was observed in 13 cases after the initial and consecutive PDT. There were 2 cases of failure. The recurrence rate was 15.4% (2/13), and the median time from the initial PDT to recurrence was 349 days.
Conclusions:
PDT using a hematoporphyrin derivative as a photosensitizer is a safe and efficient method for treating early cancer. However, a long-term follow up period using a large population sample will be needed for confirmation. (Korean J Gastrointest Endosc 2006;32:81⁣86)
Key Words: Photodynamic therapy, Esophageal cancer, Early gastric cancer, Ampulla of Vater cancer
주요어: 광역동 치료, 조기식도암, 조기위암, 유두부 종양
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