Korean J Gastrointest Endosc > Volume 33(5); 2006 > Article
Korean Journal of Gastrointestinal Endoscopy 2006;33(5): 278-284.
원발성 대장 인환세포암의 임상 및 내시경 특성
울산대학교 의과대학 서울아산병원 내과, *외과, 진단병리과
Clinical and Colonoscopic Characteristics of Primary Signet Ring Cell Carcinoma in Colorectum
Sung Hee Pyo, M.D., Jeong-Sik Byeon, M.D., Seung-Jae Myung, M.D., Suk-Kyun Yang, M.D., Hyung Joon Lee, M.D., Seung Il Pyo, M.D., Jin-Ho Kim, M.D., Jin Cheon Kim, M.D.* and Se Jin Jang, M.D.
Departments of Internal Medicine, *Surgery and Diagnostic Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

A primary signet ring cell carcinoma (SRCC) in the colorectum is unusual. This study evaluated the clinical and colonoscopic characteristics of primary colorectal SRCC.
Twenty-eight patients diagnosed with a primary colorectal SRCC and 100 patients diagnosed with a primary colorectal nonmucinous adenocarcinoma were enrolled in this study. The medical records and colonoscopic findings were reviewed.
The mean age was younger in the SRCC patients than in the nonmucinous adenocarcinoma patients (47.3±15.5 years vs. 60.3±10.4 years, p<0.001). In SRCC, hematochezia was less frequent while abdominal pain was more common (p<0.001). Duke stages A or B was rare in SRCC (4/28, 14.3% vs. 58/100, 58.0%, p<0.001). The colonoscopic features of Borrmann type 4 was more common in SRCC (10/28, 35.7% vs. 3/100, 3.0%, p<0.001). The occurrence of a tumor in the right colon was more frequent in SRCC (17/28, 60.7% vs. 20/100, 20.0%, p<0.001). The diagnostic yield of the first colonoscopic biopsy was lower in the SRCC patients (85.7% vs. 98.0%, p=0.021).
Primary colorectal SRCC appears to occur in younger patients compared with nonmucinous adenocarcinoma. A more advanced stage and an infiltrative lesion such as Borrmann type 4 appears to be common and the diagnostic yield of a colonoscopic biopsy tends to be low in primary colorectal SRCC. (Korean J Gastrointest Endosc 2006;33:278⁣284)
Key Words: Signet ring cell carcinoma, Colorectal adenocarcinoma, Colonoscopy, Biopsy
주요어: 인환세포암, 대장 선암, 대장내시경, 조직 생검
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