Korean J Gastrointest Endosc > Volume 33(5); 2006 > Article
Korean Journal of Gastrointestinal Endoscopy 2006;33(5): 271-277.
만성 위축성 위염에서 TGF-β1의 발현
김규종·이진혁·정훈용·홍성수·정진용·이선미·남원희·변정식·명승재·양석균·홍원선·김진호·민영일·김정선*
울산대학교 의과대학 서울아산병원 소화기내과학교실, *진단병리학교실
The Expression of TGF-β1 in Patients with Chronic Atrophic Gastritis
Kyu-Jong Kim, M.D., Gin Hyug Lee, M.D., Hwoon-Yong Jung, M.D., Seong Soo Hong, M.D., Jin-Yong Jeong, Ph.D., Sun-Mi Lee, B.S., Won-Hee Nam, B.S., Jeong-Sik Byeon, M.D., Seung-Jae Myung, M.D., Suk-Kyun Yang, M.D., Weon-Seon Hong, M.D., Jin-Ho Kim, M.D., You
Division of Gastroenterology, Departments of Internal Medicine and *Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Abstract

Background/Aims:
Mucosal atrophy is defined as the loss of appropriate glands in the gastric mucosa; such a finding suggests that this malady is associated with an excessive ratio of apoptotic cells to proliferating epithelial cells. However, exactly why the genesis and progression of the atrophic changes takes place in the gastric mucosa of some, but not all of the subjects infected with H. pylori, is seldom described. TGF-β1 (transforming growth factor-β1) is a potent growth inhibitor in epithelial tissues, and it also induces apoptosis of epithelial cells. We evaluated its role in the pathogenesis of atrophic gastritis by analyzing the expression of TGF-β1.
Methods:
The subjects were 14 patients with chronic atrophic gastritis and 43 patients with chronic gastritis. The exclusion criteria were as follows; those patients who had a previous history of gastrectomy, PPI, H. pylori eradication, NSAIDs, stomach cancer and/or a severe bleeding tendency. Biopsy specimens were obtained from the antrum, angle and body of the stomach, respectively and we performed RT-PCR for determining the expression of TGF-β1 mRNA with using an additional angle specimen.
Results:
The clinical parameters were similar in both groups. The rate of H. pylori infection was also similar in both groups. The TGF-β1 levels were significantly higher for the chronic atrophic gastritis group than for the chronic gastritis group.
Conclusions:
The results that the TGF-β1 levels are significantly higher in the chronic atrophic gastritis group suggest that TGF-β1 is associated with the development of atrophic gastritis. The apoptotic process induced by TGF-β1 may be linked to the development of atrophic gastritis. (Korean J Gastrointest Endosc 2006;33:271-277)
Key Words: Chronic atrophic gastritis, Apoptosis, TGF-β1
주요어: 만성 위축성 위염, 세포 고사, TGF-β1
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