Korean J Gastrointest Endosc > Volume 34(4); 2007 > Article
Korean Journal of Gastrointestinal Endoscopy 2007;34(4): 193-199.
소아 크론병의 임상적 특징과 경과
부산성모병원 소아과, *부산대학교 의과대학 소아과학교실
Clinical Features and Course of Crohn Disease in Children
Na Young Lee, M.D. and Jae Hong Park, M.D.*
Department of Pediatrics, Busan St. Mary's Medical Center, *Pusan National University Hospital, Busan, Korea

The aim of this study was to evaluate the clinical features and course of Crohn disease (CD) in children.
The medical records of 30 patients diagnosed with CD between January 1996 and December 2005 were reviewed retrospectively.
The actual number of newly diagnosed patients with CD has increased during the 8-year period. The male/female ratio was 2:1 and the mean age at diagnosis was 10.6⁑4.3 years. The major symptoms of CD at diagnosis were abdominal pain (79.2%), weight loss (54.2%), perianal lesion (54.2%), diarrhea (45.8%), hematochezia (41.7%), anemia (29.2%), and fever (23.3%). The disease location of CD was the small bowel in 33.3%, the large bowel in 12.5% and both the small and large bowel in 54.2%. Granuloma was found in 54.2% of patients. The relapse rate of CD in the group with a higher pediatric Crohn disease activity index (PCDAI) at diagnosis (≥30) was higher than in the group with a lower PCDAI (<30). The cumulative relapse rates of the patients with granuloma were 30.2% within 1 year and 53.8% within 5 years after the diagnosis.
The incidence of CD in children appears to be increasing. Granuloma formation and a higher score of the PCDAI are associated with a more severe disease course. Pediatric CD may have a somewhat different clinical presentation from older-onset CD. (Korean J Gastrointest Endosc 2007;34:193⁣199)
Key Words: Crohn disease, Children
주요어: 크론병, 소아
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