Korean J Gastrointest Endosc > Volume 36(5); 2008 > Article
Korean Journal of Gastrointestinal Endoscopy 2008;36(5): 257-261.
위선종 또는 조기위암으로 내시경적 점막절제술을 받은 환자에서 Helicobacter pylori 재감염과 이시성 재발
허민ㆍ김병욱ㆍ이보인ㆍ최황ㆍ조세현ㆍ지정선ㆍ최규용ㆍ김민국ㆍ정현정ㆍ장정원ㆍ채현석ㆍ정인식
가톨릭대학교 의과대학 내과학교실
The Re-infection of Helicobacter pylori and the Presence of Metachronous Lesions after Endoscopic Mucosal Resection of Gastric Neoplasias
Min Huh, M.D., Byung Wook Kim, M.D., Bo In Lee, M.D., Hwang Choi, M.D., Se Hyun Cho, M.D., Jeong Seon Ji, M.D., Kyu Yong Choi, M.D., Min Kuk Kim, M.D., Hyun Jung Jung, M.D., Jeong Won Jang, M.D., Hiun Suk Chae, M.D. and In Sik Chung, M.D.
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract

Background/Aims:
The aims of this study were to determine the H. pylori re-infection rate in patients that underwent endoscopic mucosal resection (EMR) due to a gastric adenoma and gastric adenocarcinoma, and to define the correlation between H. pylori re-infection and the presence of metachronous lesions.
Methods:
An endoscopic examination with a biopsy was performed at six months, 12 months, and every year thereafter to determine if H. pylori re-infection occurred and if metachronous lesions were present in patients that had undergone EMR (EMR group). At least a three-year follow-up examination was performed, and patients with an on-site recurrent lesion were excluded. The re-infection rate was compared to the rate in patients with peptic ulcers (control group).
Results:
Six patients (24%) among the 25 patients included in this study had H. pylori re-infection, an indication of a high re-infection rate as compared to the rate in patients with peptic ulcers (p=0.03). Two patients (33.3%) who were re-infected with H. pylori had metachronous lesions (p=0.009).
Conclusions:
Determination of the H. pylori status during a follow-up study after EMR is essential and re-eradication therapy is recommended in patients with H. pylori re-infection to prevent metachronous lesions. (Korean J Gastrointest Endosc 2008;36: 257-261)
Key Words: Endoscopic mucosal resection, H. pylori, Metachronous lesions
주요어: 내시경적 점막절제술, H. pylori, 이시성 재발
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