Korean J Gastrointest Endosc > Volume 37(3); 2008 > Article
Korean Journal of Gastrointestinal Endoscopy 2008;37(3): 167-173.
대장내시경 전처치로서 4 L Polyethylene Glycol (PEG) 용액의 복용과 2 L PEG 용액 및 비사코딜 병합요법의 비교 분석
이화여자대학교 의학전문대학원 내과학교실, 의과학연구소
A Prospective Trial Comparing 4 L-Polyethylene Glycol with 2 L-Polyethylene Glycol Plus Bisacodyl Tablets for Colon Preparation
Min-Jung Kang, M.D., Sung-Ae Jung, M.D., Ji Min Jung, M.D., Hyun Joo Song, M.D., Seong-Eun Kim, M.D., Hye-Kyung Jung, M.D., Ki-Nam Shim, M.D., Kwon Yoo, M.D. and Il-Hwan Moon, M.D.
Department of Internal Medicine, Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea

The aim of the study was to prospectively compare low-volume PEG plus 20 mg bisacodyl with the standard 4 L PEG with regards to the adequacy of bowel preparation, patient compliance and the side effects.
From September 2007 to January 2008, 59 patients who had previously undergone screening colonoscopy with 4 L PEG and had been diagnosed with colonic polyps were admitted for polypectomy. The colonoscopists, who were unaware of the preparation that was administered, evaluated the adequacy of the bowel cleansing. Detailed questionnaires were also used to assess patient compliance, the difficulty of bowel preparation, side effects and patient preference.
The physician's evaluation of the colon cleansing showed better adequacy with 4 L PEG than with 2 L PEG plus bisacodyl (p<0.05). There was no difference in patient compliance between the 2 bowel preps. The patients in the 2 L PEG plus bisacodyl group tolerated the bowel preparation more easily than the patients in the 4 L PEG (81.4% vs. 15.3%, respectively). Moreover, the scores of the visual analog scale for the difficulty of bowel preparation were 5.8±2.3 in the 4 L PEG group and 3.2±1.9 in the 2 L PEG plus bisacodyl (p<0.01). The majority (89.8%) of the patients preferred 2 L PEG plus bisacodyl (p<0.001). The 2 L PEG plus bisacodyl group revealed less nausea, vomiting and sleep discomfort (p<0.05), but they had more abdominal pain (p<0.01).
2 L PEG plus bisacodyl is not as effective as the standard 4 L PEG for colon cleansing. However, 2 L PEG plus bisacodyl can be used for patients who have difficulty drinking a large amount of PEG. (Korean J Gastrointest Endosc 2008;37:167-173)
Key Words: Bisacodyl, Polyethylene glycol, Colonoscopy, Bowel preparation
주요어: 비사코딜, Polyethylene glycol, 대장내시경, 대장 정결
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