Korean J Gastrointest Endosc > Volume 37(4); 2008 > Article
Korean Journal of Gastrointestinal Endoscopy 2008;37(4): 299-302.
직장으로 점막하 전이된 원발성 항문 흑색종 1예
봉생병원 내과
A Case of Primary Melanoma of the Anus that Spread to the Submucosa of the Rectum
Sung Whan Cho, M.D., Won Il Park, M.D., Hyung Yook Kim, M.D., Kwang Jin Kim, M.D. and Ung Suk Yang, M.D.
Division of Gastroenterology, Department of Internal Medicine, Bong Seng Memorial Hospital, Busan, Korea
Primary malignant melanoma of the anorectum is rare, representing about 1% of all colorectal carcinoma and less than 1% of all melanomas. The most common symptom of malignant melanoma of the anorectum is anal bleeding and this is often misdiagnosed as hemorrhoids. A 72-year-old female patient was admitted due to intermittent anal bleeding for 6 months. Colonoscopic examination showed a large exophytic mass with an irregularly ulcerated and greenish-brown pigmentation on the anus and the examination also simultaneously showed a submucosal tumor-like lesion in the rectum that was located 5 cm from the anal verge. Light microscopy of the tumor revealed malignant melanocytes and the tumor cells reacted positively for immunohistochemical staining with S-100 protein and HMB-45. Distant metastasis to the brain was detected on brain MRI. (Korean J Gastrointest Endosc 2008;37:299-302)
Key Words: Anorectal malignant melanoma, Submucosal metastasis
주요어: 항문직장 흑색종, 점막하 전이
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