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Clin Endosc : Clinical Endoscopy



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HOME > Clin Endosc > Volume 38(3); 2009 > Article
A Case of Langerhans Cell Histiocytosis That Involved the Colon
[Epub ahead of print]
Published online: March 30, 2009
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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A 34-year-old man was referred to our department for evaluation of his elevated liver function test. He was diagnosed with Langerhans cell histiocytosis 7 years ago because of recurrent pneumothorax. A CT scan showed multifocal intrahepatic duct dilatation with soft tissue infiltration in the right lobe of the liver. An ERCP showed diffuse multifocal strictures of the intrahepatic duct intervening among the normal segments of the duct. A percutaneous needle biopsy of the liver disclosed ductular proliferation, inflammatory cell infiltration and focal cholestasis. Therefore, he was diagnosed with sclerosing cholangitis. He underwent colonoscopy to evaluate for the possibility of ulcerative colitis. The colonoscopy showed erosions and erythema on the mucosa of the appendiceal orifice, another site of erosion at 35 cm from the anal verge and multiple 3~8 mm sized sessile polyps. Biopsies of the colon mucosa disclosed an infiltration of Langerhans cell histiocytosis. We report here on a very rare case of colon involvement of Langerhans cell histiocytosis. (Korean J Gastrointest Endosc 2009;38:166-170)

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