Korean J Gastrointest Endosc > Volume 39(2); 2009 > Article
Korean Journal of Gastrointestinal Endoscopy 2009;39(2): 66-71.
한국인에서 Propofol을 이용한 상부 위장관 내시경 검사시 진정 유도에 필요한 적정 용량
광주기독병원 내과
The Adequate Dose of Propofol for Inducing Sedation during Performance of Upper Gastrointestinal Endoscopy in Koreans
Gun Young Hong, M.D., Kang Seok Seo, M.D., Sang Wook Park, M.D., Hyeung Cheol Moon, M.D., Sang Chul Choi, M.D. and Yeun Keun Lim, M.D.
Department of Internal Medicine, Kwangju Christian Hospital, Gwangju, Korea

Propofol sedation is increasingly being used when performing upper gastrointestinal endoscopy because of its rapid onset and good recovery profile. For achieving safe sedation during endoscopy, close monitoring of the vital signs is necessary because of the sedation's potentially serious adverse effects. There are only a few studies on the induction of sedation with using propofol for endoscopy in Korea. The present study was undertaken to evaluate the adequate initial injected dose of propofol for achieving safe and effective sedation when performing upper gastrointestinal endoscopy in Koreans.
From March 2008 to July 2008, 150 subjects who visited Kwangju Christian Hospital were randomized into 3 groups. An initial bolus dose of 0.5 mg/kg, 1.0 mg/kg and 1.5 mg/kg of propofol was allocated to groups A, B and C, respectively. The effectiveness and safety profiles of each injected dose of propofol were prospectively assessed by measuring various parameters of the vital signs and the adverse events.
Group C had a significantly shorter induction time and the patients in group C did not require additional injections of propofol without increasing adverse events, as compared to that of the other 2 groups.
1.5 mg/kg of propofol was found to be more appropriate than 0.5 mg/kg or 1.0 mg/kg of propofol as the initial injected dose for induction of sedation during performance of upper gastrointestinal endoscopy in Koreans. (Korean J Gastrointest Endosc 2009;39:66-71)
Key Words: Propofol, Initial dose, Endoscopy
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
Related articles
Aerosol protection using modified N95 respirator during upper gastrointestinal endoscopy: a randomized controlled trial  
Management of aerosol generation during upper gastrointestinal endoscopy  2022 September;55(5)
Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy  2020 September;53(5)
Updates on the Sedation for Gastrointestinal Endoscopy  2019 September;52(5)
Adverse Events by Sedation Type in Gastrointestinal Endoscopy  2017 March;50(2)
Editorial Office
Korean Society of Gastrointestinal Endoscopy
#817, 156 Yanghwa-ro (LG Palace, Donggyo-dong), Mapo-gu, Seoul, 04050, Korea
TEL: +82-2-335-1552   FAX: +82-2-335-2690    E-mail: CE@gie.or.kr
Copyright © Korean Society of Gastrointestinal Endoscopy.                 Developed in M2PI
Close layer