Korean J Gastrointest Endosc > Volume 39(6); 2009 > Article
Korean Journal of Gastrointestinal Endoscopy 2009;39(6): 374-378.
전신 질환 및 경구 철분 제재와 연관된 십이지장 가성흑색증 2예
순천향대학교 의과대학 천안병원 내과학교실, *병리학교실
Two Cases of Pseudomelanosis Duodeni Associated with Systemic Diseases and Oral Iron Supplementation
Kyoung-Hwan Lee, M.D., Tae Hoon Lee, M.D., Yun Suk Shim, M.D., Jun-Ho Choi, M.D., Il-Kwun Chung, M.D., Sang-Heum Park, M.D., Sun-Joo Kim, M.D. and Mee-Hye Oh, M.D.*
Departments of Internal Medicine and *Pathology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea
Pseudomelanosis duodeni is a rare benign condition that manifests endoscopically as diffuse, small brownish-black spots in the duodenal mucosa, and the histochemical findings show an accumulation of hemosiderin pigment in the duodenal villi's lamina propria. This condition produces no specific symptoms, and it may be reversible. The cause and natural history of the pigmentation have not been clarified, although it is associated with a variety of systemic illnesses and medications. We describe two cases of pseudomelanosis duodeni and the patients had histories of diabetes mellitus, hypertension, chronic renal insufficiency and specific medications. We also review the relevant medical literature on this rare condition. (Korean J Gastrointest Endosc 2009;39:374-378)
Key Words: Melanosis, Hemosiderin, Duodenum
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