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Korean J Gastrointest Endosc > Volume 40(1); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;40(1): 27-30.
X 연관성 무감마글로불린혈증 환자에서 발생한 위샘암종 1예
옥창수ㆍ이준행ㆍ노정원ㆍ손서영ㆍ장복순ㆍ구본호ㆍ고원중ㆍ성창옥*
성균관대학교 의과대학 삼성서울병원 내과, *병리과
A Case of Gastric Adenocarcinoma in a Patient with X-linked Agammaglobulinemia
Chang Soo Ok, M.D., Jun Haeng Lee, M.D., Jung Won Noh, M.D., Seo Young Sohn, M.D., Bok Soon Chang, M.D., Bon-Ho Ku, M.D., Won-Jung Koh, M.D. and Chang Ohk Sung, M.D.*
Departments of Internal Medicine and *Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Abstract
X-linked agammaglobulinemia is a common type of primary immunodeficiency disorder that's caused by mutation of the BTK gene. The absence of B lymphocytes and plasma cells causes recurrent infections. Patients with X-linked agammaglobulinemia also have a high risk for developing hematological malignancies and, to a lesser degree, carcinoma. We report here on a 26-years-old male patient who suffered with X-linked agammaglobulinemia that was caused by BTK gene mutation, and he developed a gastric cancer in the antrum. He was noted to have chronic atrophic gastritis and diffuse intestinal metaplasia on the endoscopic examination that was done 7 years previously. We recommend regular esophagogastroduodenoscopic evaluation for a patient with X-linked agammaglobulinemia in order to make an early diagnosis of stomach carcinoma. (Korean J Gastrointest Endosc 2010;40:27-30)
Key Words: X-linked agammaglobulinemia, Stomach cancer
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