Korean J Gastrointest Endosc > Volume 40(5); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;40(5): 297-302.
거대 Brunner 종양 국내보고 39예의 임상적 고찰
동국대학교 의과대학 내과학교실, *병리학교실
Clinical Characteristics of Large Brunner's Gland Tumors in Korea
Ji Hun Kang, M.D., Yun Jeong Lim, M.D., Suk Jae Hahn, M.D., Jong Sun Choi, M.D.*, Moon Soo Koh, M.D. and Jin Ho Lee, M.D
Departments of Internal Medicine and *Pathology, Dongguk University College of Medicine, Seoul, Korea

Brunner's gland tumor is a common benign tumor noted in duodenum and might be designated as Brunner's gland hamartoma, adenoma or hyperplasia. But, a large duodenal polyp (over 1 cm in diameter) pathologically proven as a tumor of Brunner's gland origin is rare.
We analyzed a total of 39 cases including our direct experience of two cases and reports of 37 cases to clarify the clinical features of large Brunner's gland tumors.
This tumor tends to present predominantly after the fourth decade: Median age is 52.6 years. Neither gender showed predominance. The size of the tumor ranged from 1 to 8 cm and the mean diameter was 2.9 cm. The most common location was the bulb. A pedunculated polyp was the common appearance. Epigastric pain was the most common symptom. Brunner's gland tumor can cause gastrointestinal hemorrhage or obstruction. Most of the polyps had non-diagnostic pathologic yield at pinch biopsy and only one case was diagnosed as focal adenocarcinoma. Endoscopic or surgical removal was undertaken for treatment. Most cases had no recurrence after removal. Snare polypectomy or submucosal dissection very safe and useful treatment modalities.
Large Brunner's gland tumors are mostly found during a check up or epigastric pain. Anemia, melena and obstruction often develop. Endoscopic polypectomy is recommended as a first line treatment. (Korean J Gastrointest Endosc 2010;40:297-302)
Key Words: Brunner's gland hamartoma, Brunner's gland adenoma, Brunner's gland hyperplasia
주요어: Brunner 과오종, Brunner 선종, Brunner 과증식
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