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HOME > Clin Endosc > Volume 41(1); 2010 > Article
A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy
[Epub ahead of print]
Published online: July 31, 2010
Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea
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/Aims: We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy.
A total of 133 patients undergoing colonoscopy were randomized to receive either 20 mg of hyoscine-N-butyl bromide (n=70) or normal saline solution (n=63) via intramuscular injection as premedication.
The mean cecal intubation time and withdrawal time in the hyoscine- N-butyl bromide group were significantly shorter than those of the control group (5.26±2.78 min vs. 6.74±4.89 min; p=0.032, 5.42±1.54 min vs. 6.18±2.54 min; p=0.038, each). The spasm grade in the hyoscine-N-butyl bromide group was significantly lower than that of the control group (p<0.001). No significant differences were found in the polyp detection rate (15.7% vs. 28.6%; p=0.073) and adenoma detection rate (10.0% vs. 15.9%; p=0.311). Difficulty of colonoscopy for the endoscopists and nurses (p=0.853; p=0.732), the patient's comfort (p=0.891) and the patient's willingness to repeat colonoscopy (85.7% vs. 82.5%; p=0.932) were also similar in both groups.
Premedication with intramuscularly administered hyoscine-N-butyl bromide do not demonstrate any additional benefits except reducing the colonoscopy insertion time. (Korean J Gastrointest Endosc 2010;41:10-15)

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