Recent Eradication Rates of First-line Triple Regimens for H. pylori Infection

Korean J Gastrointest Endosc > Volume 41(1); 2010 > Article

Korean Journal of Gastrointestinal Endoscopy 2010;41(1): 5-9.

최근 H. pylori에 대한 1차 삼제요법의 연도별 제균율 변화와 기간에 따른 제균율 비교

백나영*ㆍ임윤정ㆍ이종호ㆍ강지훈ㆍ박정배ㆍ이진호

동국대학교 의과대학 내과학교실, *가정의학교실

Recent Eradication Rates of First-line Triple Regimens for H. pylori Infection

Na Young Paek, M.D.*, Yun Jeong Lim, M.D., Jong Ho Lee, M.D., Ji Hun Kang, M.D., Jeong Bae Park, M.D. and Jin Ho Lee, M.D.

Departments of Internal Medicine, *Family Medicine, Dongguk University-Seoul, Graduate School of Medicine, Goyang, Korea

Abstract

Background/Aims:
Decreasing trend of eradication rate of H. pylori using first-line triple regimens (proton pump inhibitor, amoxicillin, clarithromycin) has been issued. Longer therapies may become more popular if there are better results. Recent eradication rate should be examined and proper recommendation should be timely done according to the result.
Methods:
We examined recent eradication rates of first-line triple regimens and compared eradication rate according to the duration of this first-line therapy for H. pylori infection. The 976 patients received first-line triple therapy at the single center from November, 2005 to October, 2009 were retrospectively analyzed. Urea breath test was done at four to six weeks after completion of eradication therapy.
Results:
Overall eradication rate of triple regimen by intention to treat analysis was 80.4% (785/976). One week eradication rate has decreasing trend and below 73.3% during recent 2 years. Eradication rate in 2 weeks group (83.3%, 165/198) was significantly higher than 1 week group (73.3%, 198/270) from November, 2007 to October, 2009 (p＜0.01).
Conclusions:
Our results showed that 2 weeks triple regimen should be preferred as first-line therapy for H. pylori eradication. (Korean J Gastrointest Endosc 2010; 41:5-9)

Key Words: Helicobacter pylori, Eradication

주요어: Helicobacter pylori, 제균 치료