Korean Journal of Gastrointestinal Endoscopy 2010;41(4): 208-213.
식도의 원발성 NK-/T- 세포 림프종 1예
김태형ㆍ류호상ㆍ김창하ㆍ홍호철ㆍ고진성ㆍ전훈재ㆍ김창덕ㆍ김인선*
고려대학교 의과대학 내과학교실, *병리학교실
Primary NK-/T- Cell Lymphoma of the Esophagus: a Case Presentation and Literature Review
Tae Hyung Kim, M.D., Ho Sang Ryu, M.D., Chang Ha Kim, M.D., Hocheol Hong, M.D., Jin-Sung Koh, M.D., Hoon Jai Chun, M.D., Chang Duck Kim, M.D. and Insun Kim, M.D.*
Departments of Internal Medicine, *Pathology, Korea University College of Medicine, Seoul, Korea
Abstract
Extranodal natural killer/T-cell lymphoma (ENKL) is an uncommon neoplasm, and it is a subtype of non-Hodgkin's lymphoma. It most commonly presents in the nasal cavity and nasopharynx. But only 10% of ENKL may present on the skin or the gastrointestinal tract and this has a poor prognosis. We report here on a case of CD56＋ NK/T-cell lymphoma that limited to the esophagus. A 55-year-old male patient presented with epigastric soreness. Esophagogastroduodenoscopy (EGD) showed well demarcated, longitudinal ulcerative lesions with an irregular base and a discrete margin on the lower esophagus. We performed EGDs and endoscopic biopsies 2 times, but these were insufficient to make a diagnosis. The 3rd time, we finally took a big piece of tissue using endoscopic mucosal resection with a cap-fitted panendoscope (EMR-C). The biopsies showed surface ulceration and a heavy lymphoid infiltration and a positive pattern for CD3, CD56 and granzyme B. The pathologic diagnosis was NK/T-cell lymphoma. The patient was treated with concurrent chemoradiation followed by additional chemotherapy and he achieved a complete response. (Korean J Gastrointest Endosc 2010;41:208-213)
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