Korean J Gastrointest Endosc > Volume 41(4); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;41(4): 208-213.
식도의 원발성 NK-/T- 세포 림프종 1예
고려대학교 의과대학 내과학교실, *병리학교실
Primary NK-/T- Cell Lymphoma of the Esophagus: a Case Presentation and Literature Review
Tae Hyung Kim, M.D., Ho Sang Ryu, M.D., Chang Ha Kim, M.D., Hocheol Hong, M.D., Jin-Sung Koh, M.D., Hoon Jai Chun, M.D., Chang Duck Kim, M.D. and Insun Kim, M.D.*
Departments of Internal Medicine, *Pathology, Korea University College of Medicine, Seoul, Korea
Extranodal natural killer/T-cell lymphoma (ENKL) is an uncommon neoplasm, and it is a subtype of non-Hodgkin's lymphoma. It most commonly presents in the nasal cavity and nasopharynx. But only 10% of ENKL may present on the skin or the gastrointestinal tract and this has a poor prognosis. We report here on a case of CD56+ NK/T-cell lymphoma that limited to the esophagus. A 55-year-old male patient presented with epigastric soreness. Esophagogastroduodenoscopy (EGD) showed well demarcated, longitudinal ulcerative lesions with an irregular base and a discrete margin on the lower esophagus. We performed EGDs and endoscopic biopsies 2 times, but these were insufficient to make a diagnosis. The 3rd time, we finally took a big piece of tissue using endoscopic mucosal resection with a cap-fitted panendoscope (EMR-C). The biopsies showed surface ulceration and a heavy lymphoid infiltration and a positive pattern for CD3, CD56 and granzyme B. The pathologic diagnosis was NK/T-cell lymphoma. The patient was treated with concurrent chemoradiation followed by additional chemotherapy and he achieved a complete response. (Korean J Gastrointest Endosc 2010;41:208-213)
Key Words: Extranodal NK-T-cell lymphoma, Esophageal primary ulcer, Complete response
주요어: 림프절 외 NK/T 세포 림프종, 식도 원발성 궤양, 완전 관해
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