Korean J Gastrointest Endosc > Volume 41(5); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;41(5): 312-318.
재발성 궤양성 대장염 환자에서 병발한 괴저고름피부증 2예
권용환ㆍ김재우ㆍ박소연ㆍ김문영ㆍ김현수ㆍ백순구ㆍ쟘시드 압둘 가파*ㆍ조미연*
연세대학교 원주의과대학 내과학교실, *병리학교실
Two Cases of Pyoderma Gangrenosum Associated with Recurrent Ulcerative Colitis
Yong Hwan Kwon, M.D., Jae Woo Kim, M.D., So Yeon Park, M.D., Moon Young Kim, M.D., Hyun Soo Kim, M.D., Soon Koo Baik, M.D., Jamshid Abdul-Ghafar, M.D.* and Mee Yon Cho, M.D.*
Departments of Internal Medicine and *Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea
Abstract
Pyoderma gangrenosum (PG) begins with a painful, erythematous skin lesion followed by pustule formation and rapid ulceration in which an erythematous border surrounds a sterile, necrotic center. In most patients, symptoms of ulcerative colitis precede PG, and exacerbations of the bowel disease frequently correlate with worsening of the skin lesions. As PG is not commonly encountered by clinicians, the diagnosis of such lesions is not always straightforward. This case emphasizes the importance of detailed history taking and the consideration of PG as a differential diagnosis of such lesions in patients with a background of related systemic disease. The prognosis of PG is generally good. But, early aggressive therapy can minimize severe complications, and maintenance treatment may prevent some devastating consequences. We report two cases of PG that developed on the entire body and on an anterior chest wall abscess with ulcerative colitis, which improved with corticosteroid and cyclosporine. (Korean J Gastrointest Endosc 2010;41:312-318)
Key Words: Pyoderma gangrenosum, Ulcerative colitis, Corticosteroid, Cyclosporine
주요어: 괴저고름피부증, 궤양성 대장염, 스테로이드, 사이클로스포린
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