Hyperplastic gastric polyp, Helicobacter pylori, Eradication, Regression, Predictive factor"/> Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication
Korean J Gastrointest Endosc > Volume 42(2); 2011 > Article
Korean Journal of Gastrointestinal Endoscopy 2011;42(2): 74-82.
헬리코박터 양성인 과증식 위용종 환자에서 제균 치료 후 용종 소실에 관한 연구
임상아ㆍ윤재원ㆍ윤대웅ㆍ최원재ㆍ김승한ㆍ최정완ㆍ김미나ㆍ강은주ㆍ박종재ㆍ주문경ㆍ이범재ㆍ박영태ㆍ이상우ㆍ박종태*
고려대학교 의과대학 내과학교실, *산업의학교실
Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication
Sang-Ah Lim, M.D., Jae-Won Yun, M.D., Daewoong Yoon, M.D., Wonjae Choi, M.D., Seung Han Kim, M.D., Jung Wan Choe, M.D., Mi-Na Kim, M.D., Eun Joo Kang, M.D., Jong Jae Park, M.D., Moon Kyung Joo, M.D., Beom Jae Lee, M.D., Young-Tae Bak, M.D., Sang Woo Lee,
Department of Internal Medicine, Korea University College of Medicine, Seoul, *Department of Occupational & Environmental Medicine, Korea University College of Medicine, Ansan, Korea
Abstract

Background/Aims:
Recent studies have suggested that the eradication of Helicobacter pylori (Hp) may lead to the regression of hyperplastic polyps (HPPs) in the stomach. We evaluated the sizes of HPPs after Hp eradication and we also compared the clinical parameters between the regression and non-regression groups.


Methods:
We enrolled 187 patients who had HPPs in the stomach. The polyps were measured by using biopsy forceps, and the endoscopically observed changes of the polyps were assessed by two endoscopists.


Results:
Total regression was observed in 68 patients of the eradicated group and in 6 patients in the non-eradicated group (42.5% vs. 22.2%, respectively, p0.05). The non regression rate was significantly higher for the non-eradicated group than that for the eradicated group (33% vs. 10%, respectively, p0.05). Comparing between the regression and non-regression groups, the incidence of polyps that were smaller than 10 mm in size and sessile was significantly higher in the regression group. Hp eradication was the only significant predictor of regression.


Conclusions:
Hp eradication could be a therapeutic option for Hp positive-hyperplastic gastric polyps, and especially for those that are less than 10 mm in size and sessile. (Korean J Gastrointest Endosc 2011;42:74-82)

Key Words: Hyperplastic gastric polyp, Helicobacter pylori, Eradication, Regression, Predictive factor
주요어: 과증식 위용종, 헬리코박터, 제균, 소실, 예측 인자
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