Korean Journal of Gastrointestinal Endoscopy 2011;43(1): 56-59.
말단 회장과 횡행 결장의 궤양에서 미성숙 육아종을 보인 장티푸스 1예
윤상구ㆍ김남훈ㆍ김민환ㆍ박주현ㆍ배원기ㆍ김경아ㆍ이준성ㆍ김한성*
인제대학교 의과대학 일산백병원 내과학교실, *병리학교실
Ill-defined Granulomas Demonstrated in Ulcers of the Terminal Ileum and Transverse Colon in a Patient with Typhoid Fever
Sang Gu Yun, M.D., Nam-Hoon Kim, M.D., Min Hwan Kim, M.D., Joo Hyun Park, M.D., Won Ki Bae, M.D., Kyung-Ah Kim, M.D., June Sung Lee, M.D. and Han Sung Kim, M.D.*
Departments of Internal Medicine, *Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
Abstract
Typhoid fever, the most serious human salmonellosis, is a systemic infectious disease caused by Salmonella enterica serovar Typhi and is characterized by prolonged fever, bacteremia, and multiplication of the organism within mononuclear phagocytic cells of the liver, spleen, lymph nodes, and Peyer's patches. The characteristic lesion of typhoid fever is an ulceration of the small intestinal lymphoid tissue, particularly the Peyer's patches. The usual histological findings of typhoid ulcer are necrosis and histiocytic proliferation that phagocytizes erythrocytes and degenerated lymphocytes. A granuloma is an unusual histopathological presentation of a typhoid lesion. Even if granulomas have been reported in the bone marrow, liver, and spleen in cases of typhoid fever, granulomas in primary ulcers of the ileum and transverse colon have been reported very rarely. We experienced a case of typhoid fever in which ill-defined granulomas were seen in ulcers of the terminal ileum and transverse colon. (Korean J Gastrointest Endosc 2011;43:56-59)
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