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HOME > Clin Endosc > Volume 43(1); 2011 > Article
A Case of Churg-Strauss Syndrome Manifesting as Colonic Aphthous Ulcers with Granuloma
[Epub ahead of print]
Published online: July 28, 2011
Departments of Internal Medicine and *Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
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Churg-Strauss syndrome is characterized by asthma, peripheral and tissue eosinophilia, extravascular granuloma formation, and vasculitis of multiple organ systems. The gastrointestinal tract may be involved in 20% to 50% of patients, mainly with abdominal pain, diarrhea and GI bleeding. Ulcers in the small and large bowel are an uncommon manifestation, usually detected during laparotomy performed in the setting of bowel perforation. Endoscopically proven segmental colonic aphthous ulcers with typical pathologic findings such as extravascular granuloma formation, eosinophilic infiltration, or vasculitis are a rarer manifestation. We present a patient with Churg-Strauss syndrome and two aphthous ulcers in the sigmoid colon that healed after treatment with high dose steroids and cyclophosphamide. (Korean J Gastrointest Endosc 2011;43:47-51)

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