Clin Endosc > Volume 54(3); 2021 > Article
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Kim and Ahn: Diagnosis of Gastric Subepithelial Tumor: Role of Endoscopic Ultrasound-Guided Fine-Needle Biopsy


A 59-year-old woman presented with an incidental finding of a gastric subepithelial tumor (SET) (Fig.1A). The tumor appeared round in shape at the fundus of the stomach without ulceration. On endoscopic ultrasonography (EUS), the tumor measured 2.4 ×2.3 cm and had a heterogenous hypoechoic appearance in the proper muscle layer (Fig. 1B). EUS-guided fine-needle biopsy (EUS-FNB) was performed for the tumor (Fig. 1C, Fig. 2).
What is the most probable diagnosis?


Conflicts of Interest: The authors have no potential conflicts of interest.

Fig. 1.
(A) A 3-cm sized subepithelial tumor was noted at the fundus of the stomach. (B) Endoscopic ultrasonography showed a 2.4×2.3 cm round, hypoechoic mass in the proper muscle layer. (C) Endoscopic ultrasound-guided fine needle biopsy was performed.
Fig. 2.
Pathologic findings of the biopsy specimens. (A) Histopathological examination reveals uniform spindle cells with high cellularity (hematoxylin and eosin ×200). (B) The tumor cells are strongly and diffusely positive for CD117 (×200).
Fig. 3.
Macroscopic specimen from surgical resection.


1. Kim GH, Ahn JY, Gong CS, et al. Efficacy of endoscopic ultrasound-guided fine-needle biopsy in gastric subepithelial tumors located in the cardia. Dig Dis Sci 2020;65:583–590.
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2. Lee JH, Cho CJ, Park YS, et al. EUS-guided 22-gauge fine needle biopsy for the diagnosis of gastric subepithelial tumors larger than 2 cm. Scand J Gastroenterol 2016;51:486–493.
crossref pmid
3. Iglesias-Garcia J, Poley J-W, Larghi A, et al. Feasibility and yield of a new EUS histology needle: results from a multicenter, pooled, cohort study. Gastrointest Endosc 2011;73:1189–1196.
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