Clin Endosc > Volume 56(1); 2023 > Article
Nabi and Reddy: Submucosal endoscopy: the present and future


Submucosal endoscopy or third-space endoscopy utilizes the potential space between the mucosal and muscularis layers of the gastrointestinal tract to execute therapeutic interventions for various diseases. Over the last decade, endoscopic access to the submucosal space has revolutionized the field of therapeutic endoscopy. Submucosal endoscopy was originally used to perform endoscopic myotomy in patients with achalasia cardia, and its use has grown exponentially since. Currently, submucosal endoscopy is widely used to resect subepithelial tumors and to manage refractory gastroparesis and Zenker’s diverticulum. While the utility of submucosal endoscopy has stood the test of time in esophageal motility disorders and subepithelial tumors, its durability remains to be established in conditions such as Zenker’s diverticulum and refractory gastroparesis. Other emerging indications for submucosal endoscopy include esophageal epiphrenic diverticulum, Hirschsprung’s disease, and esophageal strictures not amenable to conventional endoscopic treatment. The potential of submucosal endoscopy to provide easy and safe access to the mediastinum and peritoneal spaces may open doors to novel indications and rejuvenate the interest of endoscopists in natural orifice transluminal endoscopic surgery in the future. This review focuses on the current spectrum, recent updates, and future direction of submucosal endoscopy in the gastrointestinal tract.


The submucosal or third space is a virtual space between the mucosa and muscularis layer that can be expanded using various injectable solutions and accessed endoscopically. The submucosal space provides the opportunity to manage various pathological conditions involving the submucosal and muscular layers and beyond. The concept of submucosal endoscopy originated approximately one and a half decades ago when Sumiyama et al.,1,2 in their seminal work on porcine models, showed that the peritoneal cavity and mediastinum could be successfully accessed via submucosal endoscopy, with the defect being completely sealed using the mucosal flap. The authors coined the term “submucosal endoscopy with mucosal flap safety valve (SEMF)” . Subsequently, Pasricha and colleagues suggested that the submucosal space may be exploited to perform endoscopic esophageal myotomy as a potential treatment in cases of achalasia.3 Inoue and colleagues are credited with performing the first human submucosal endoscopic myotomy in cases of achalasia cardia and coining the term per-oral endoscopic myotomy (POEM).4 Over the last decade, the use of submucosal endoscopy has witnessed exponential growth, and it is now being utilized for a number of gastrointestinal (GI) diseases such as esophageal motility disorders, subepithelial tumors (SETs), Zenker’s diverticulum, and refractory gastroparesis (Fig. 1).5
This review focuses on the current spectrum, recent updates, and future directions of submucosal endoscopy in the GI tract.



In the GI tract, submucosal endoscopy is most widely used in the esophagus. The major indications of submucosal endoscopy in the esophagus include POEM for esophageal motility disorders, submucosal tunneling endoscopic resection (STER) for SETs, submucosal tunneling with endoscopic division of septum in cases of Zenker’s diverticulum (Z-POEM) and epiphrenic diverticulum (diverticular [D]-POEM), and tunneling technique for restoration of the esophagus.

1) Esophageal motility disorders (POEM)

POEM has emerged as a safe and effective modality for the palliation of symptoms in cases of achalasia and other non-achalasia esophageal motility disorders such as diffuse esophageal spasm, jackhammer esophagus, and esophagogastric junction outflow obstruction. The POEM technique is based on the principles of SEMF and involves submucosal lifting, mucosal incision, submucosal tunneling, myotomy, and closure of the mucosal incision (Fig. 2). Multiple studies with short-term follow-ups have confirmed the safety and efficacy of POEM in esophageal motility disorders. Major adverse events (AEs) are rare with POEM and range from 0.5% to 3% in large studies using a standardized definition for defining AEs.6-8 The safety and efficacy of POEM has also been established in the pediatric age group,9 elderly population,10 spastic esophageal motility disorders,11 patients with prior treatment failure,12 and those with sigmoid achalasia.13
Emerging data indicate that the response to POEM is durable at long-term follow-ups. The long-term clinical success of POEM in recent studies has ranged from 72% to 96% at follow-up durations of 36 to 120 months (Table 1).13-29 POEM has also been compared to pneumatic dilatation (PD) and Heller’s myotomy (HM) in several retrospective cohort studies, suggesting a similar or even superior efficacy of POEM.30 More recently, two landmark randomized trials compared POEM to PD and HM.31,32 In the randomized trial comparing POEM and PD, POEM was more effective than PD at the two-year follow-up (92% vs. 54%).31 POEM and HM were equally effective after two years in another randomized trial comparing these modalities (83% vs. 82%).32 Of note, the incidence of gastroesophageal reflux disease (GERD) was higher after POEM in both studies (POEM, 41% vs. PD, 7% and POEM, 44% vs. HM, 29%). There are ample data to support the safety and efficacy of POEM in achalasia, and current international guidelines acknowledge the role of POEM as a frontline treatment modality along with PD and HM.33-37

2) Zenker’s diverticulum (Z-POEM)

The management options for Zenker’s diverticulum include surgery, rigid endoscopic diverticulotomy, and flexible endoscopic septotomy (FES). Among these, FES has gained widespread acceptance owing to its excellent safety and efficacy. However, symptoms recur in up to a third of patients after FES and are mainly attributed to incomplete division of the cricopharyngeal septum.38-40 More recently, submucosal endoscopy has been described in cases with Zenker’s diverticulum (Z-POEM) with encouraging results. The Z-POEM technique is similar to esophageal POEM for achalasia cardia. Briefly, the steps of Z-POEM include submucosal injection (saline with indigo carmine) 1 to 2 cm proximal to the septum, mucosal incision, submucosal tunneling along the Zenker’s pouch as well as along the esophageal side, division of the septum, and closure of the incision with endoclips (Fig. 3). A crucial modification in the Z-POEM technique (over the septum technique) involves submucosal elevation and mucosal incision on the top of the cricopharyngeal septum. This approach may be technically easier because of space restrictions, which impede the creation of a proximal entry in the conventional approach. Other modifications include hybrid Z-POEM in cases with submucosal fibrosis due to previous treatment and incision of the mucosa after POEM to reduce recurrences arising as a result of a remnant mucosal pouch.41
The proposed advantage of Z-POEM is its ability to completely divide the cricopharyngeal septum, which may reduce recurrence in the future. Moreover, preservation of the mucosa reduces the risk of intraprocedural perforations. Several studies have evaluated the safety and efficacy of Z-POEM in patients with Zenker’s diverticulum.42-49 In these studies, the clinical success rate was 91% to 100% at a mean follow-up of 3 to 10 months (Table 2).42-49 Meanwhile, AEs related to Z-POEM have been reported in 0% to 13.6% of cases. Although there are no randomized trials comparing Z-POEM and FES, a few retrospective comparative studies have suggested that clinical success is comparable between the two techniques.47-49

3) Esophageal epiphrenic diverticulum (D-POEM)

Esophageal epiphrenic diverticulum (EED) is a type of diverticulum that develops in the distal part of the esophagus and is typically associated with motility disorders. Surgery is the mainstay of EED management. While surgical options (thoracotomy or laparoscopy) provide symptom relief in most cases, high morbidity, especially leaks, remains an important concern. Submucosal endoscopy has emerged as a minimally invasive treatment option for patients. Broadly speaking, the technique of D-POEM is similar to that described for Zenker’s diverticulum. A key difference is that myotomy of the lower esophageal sphincter is also performed in addition to dividing the septum in selected cases with evidence of high integrated relaxation pressure. Several studies have described the results of D-POEM for EED.50-52 Nabi et al.52 described the outcomes of D-POEM in thirteen cases with EED. A co-existing esophageal motility disorder was evident in three-fourths of cases. At a median follow-up of 25 months, clinical success was achieved in 84.6% of cases. While septotomy appears to be an integral step of D-POEM, several recent studies suggest that myotomy of the lower esophageal sphincter without septotomy may provide adequate symptom relief.53,54 There are no data comparing the two approaches; therefore, it may be prudent to individualize the management approach in these cases. In a recent review, Samanta et al.55 proposed a tailored approach to EED based on the size of the diverticulum and the presence or absence of esophageal motility disorder with a non-relaxing lower esophageal sphincter. The authors suggested that septotomy may be avoided in cases with small diverticula and non-relaxing lower esophageal sphincter. Septotomy should be considered in cases with a large EED without evidence of motility disorder.

4) Refractory esophageal strictures (per-oral endoscopic tunneling for restoration of the esophagus)

Complete esophageal obstructions involving a long segment of the esophagus (>3 cm) are difficult to manage using currently available endoscopic techniques. In such cases, Wagh and colleagues reported the utility of submucosal endoscopy to restore the esophagus i.e. per-oral endoscopic tunneling for restoration of the esophagus (POETRE).56,57 In a small series including four cases with complete and long (>3 cm) segment esophageal obstruction, significant improvement in dysphagia was noted in all patients who underwent POETRE.57 Subsequently, other authors have reported the technical feasibility and efficacy of POETRE.58 Briefly, the technique of POETRE is as follows. Initially, the length of the obstructed segment is estimated by calculating the distance between the tips of the endoscopes inserted per-orally and via the gastrostomy site under fluoroscopic guidance. Depending on the location of the stricture, antegrade or retrograde (via the gastrostomy site) tunneling is performed starting a few centimeters proximal to the stricture site. Once the stenotic area is reached, careful dissection of the fibrotic scar tissue is performed until the other end of the stricture is reached. Fluoroscopic visualization of the endoscope at the other end of the stricture provides guidance during the dissection of fibrotic tissue. The aim of submucosal endoscopy in these cases is to traverse the strictured segment, after which a fully covered self-expandable metal stent is placed across the stricture. This restores the patency of the esophagus and allows the initiation of oral feeding. The metal stent is removed after 3 to 4 weeks. Subsequently, esophageal dilatations are performed at regular intervals to maintain the patency of the esophagus.


The major indications for submucosal endoscopy in the stomach include resection of SETs and management of refractory gastroparesis.

1) Refractory gastroparesis (gastric POEM or per-oral endoscopic pyloromyotomy)

A sizable proportion of patients with gastroparesis do not respond to conservative treatment, such as optimization of glycemic control, dietary modifications, and prokinetics, and are classified as having refractory gastroparesis. The management of refractory gastroparesis is challenging and often unsatisfactory. The frontrunners in the management of refractory gastroparesis include gastric electrical stimulation (GES) and laparoscopic pyloroplasty, which has been shown to be a safe and effective treatment options in recent studies.59,60 Encouraging results with surgical pyloroplasty propelled the evaluation of per-oral endoscopic pyloromyotomy (POP) or gastric POEM (G-POEM) in the management of refractory gastroparesis.
The technique of G-POEM is essentially similar to that of esophageal POEM and involves mucosal incision, tunneling, and myotomy of the pyloric sphincter (Fig. 4). The conventional G-POEM technique involves a greater curvature approach. Modifications in technique include a lesser curvature approach to pyloromyotomy and performing double pyloromyotomy instead of single pyloromyotomy.61,62 The advantages of modified techniques over and above the conventional technique remain to be seen in controlled trials. Overall, G-POEM is a safe procedure, and most AEs are mild (abdominal pain, mucosotomy, and capnoperitoneum).63
Multiple studies with short-term follow-up suggest the safety and efficacy of G-POEM (Table 3).64-69 In a systematic review including ten studies (292 patients), symptomatic improvement was achieved in 83.9% of cases at a pooled mean follow-up duration of 7.8±5.5 months.70 However, there are limited data on the long-term outcomes of G-POEM. Some of the recent studies have indicated that the efficacy of G-POEM may decline at a longer follow-up duration i.e., >1 year. In these studies, the clinical efficacy of G-POEM ranged from 48% to 69% at the one-year follow-up.64-69 The modest efficacy of G-POEM suggests the urgent need to determine the predictors of response after G-POEM to optimize its use in clinical practice. In a well-conducted, prospective, multicenter study, a baseline gastric cardinal symptom index score >2.6, gastric retention >20% at 4 hours, and early response to G-POEM at 1 month after therapy were independent predictors of clinical success at 12 months.68 In another prospective multicenter study, a predictive score was devised using several factors, including nausea, early satiety, bloating, and gastric retention at 4 hours on scintigraphy.69 Patients with scores ≥2 were significantly more likely to be responders at 3 years than patients with scores <2 (80% and 18%, respectively; p=0.001). The predictors of clinical success or failure identified in these studies need to be validated in future studies.
No randomized trial has compared G-POEM with other treatment modalities for refractory gastroparesis such as GES and surgical pyloroplasty. Limited data indicate that G-POEM may be superior to GES and equally effective to surgical pyloroplasty with the advantage of fewer AEs.71-73

2) Subepithelial tumors (STER)

Endoscopic resection techniques for SETs in the upper GI tract include endoscopic submucosal dissection, endoscopic submucosal excavation (ESE), endoscopic full-thickness resection, and STER. Of these, STER utilizes the principles of SEMF for resection of upper GI SETs (Fig. 5). The safety and efficacy of STER for SETs were confirmed in a recent systematic review and meta-analysis wherein the complete resection and en-bloc resection rates were 97.5% and 94.6%, respectively.74 Major AEs were uncommon, and minor AEs included insufflation-related AEs (14.8%) and perforation (5.6%).
Several studies have compared STER with other treatment modalities, such as ESE and video-assisted thoracoscopic surgery (VATS). In retrospective comparison studies, STER has been equally effective to ESE and VATS.75 The advantages of STER over ESE include preservation of mucosa, reduced rate of perforation, and easier closure of the mucosal defect. However, STER may be associated with a longer operating time and may be unsuitable for tumors located in the distal fundus or lesser curvature (Fig. 6).76,77 In studies comparing STER to VATS for esophageal SETs, STER has been associated with a shorter procedure duration, lower cost, and shorter hospital stay.78,79
In conclusion, an individualized approach is warranted for esophagogastric SETs. ESE may be preferred to STER in tumors located in the distal fundus or lesser curvature, and VATS may be a better option for esophageal SETs with a minor axis diameter >30 mm or tumor mass index (major axis×minor axis) >1,000.79,80


1) Hirschsprung’s disease (per-rectal endoscopic myotomy)

Hirschsprung’s disease (HD) or congenital megacolon results from the failed migration of colonic ganglion cells, resulting in the inability of a colonic segment of varying length to relax, leading to functional colonic obstruction. The aganglionic segment is usually localized in the rectosigmoid region; therefore, an endoscopic approach appears intuitive in HD. Bapaye et al.81 reported the use of submucosal endoscopy in nine cases with HD and coined per-rectal endoscopic myotomy (PREM).81 In their study, the mean length of the aganglionic segment was 6.3 cm, and all patients successfully underwent PREM with a mean procedure duration of 96 minutes and no major intraoperative AEs. At a median follow-up of 17 months (range, 9–58 months), the stool frequency improved and the requirement for laxatives was reduced in all cases.
The PREM technique is illustrated in Figure 7. First, the length of the aganglionic segment is estimated using serial biopsies at 2–3-cm intervals in the rectum. The technique of endoscopic biopsy has previously been described by the authors of this review.82,83 The subsequent steps are similar to esophageal POEM and include mucosal incision and submucosal tunneling until the predetermined extension of the aganglionic segment followed by myotomy and closure of the mucosal incision with endoclips (Fig. 7). Caution is advised while performing myotomy close to the anal verge to avoid inadvertent damage to the external anal sphincter. Barring this study, the data are limited regarding the utility of PREM in HD. Therefore, large-scale studies with long-term follow-ups are required before PREM can be advocated in routine clinical practice.


The field of submucosal endoscopy is over a decade old. However, new information and advancements are constantly enriching the wisdom of third-space endoscopists. In this section, we discuss the recent progress in submucosal endoscopy (Table 4).
While the safety and efficacy of POEM have been established in studies published over the last decade, more recent studies have focused on the efficacy of short esophageal myotomy,84-87 prevention of postoperative GERD, and the utility of the endoluminal functional lumen imaging probe (EndoFLIP) in predicting the outcomes of POEM.88-91
The length of esophageal myotomy during POEM is usually 6 to 8 cm based on the initial description of the procedure by experts. However, the same is not evidence-based, and recent studies have questioned the utility of long esophageal myotomies in achalasia. Several randomized trials and systematic reviews have concluded that short esophageal myotomy (3–5 cm) is equally effective, with the advantage of reduced procedure duration and possibly less esophageal acid exposure as compared to those associated with standard esophageal myotomy.92 In a recent study, the distensibility index (DI) of the lower esophageal sphincter fell within the target range for most patients following a 2–4-cm esophageal myotomy, further supporting the efficacy of short esophageal myotomy in patients with achalasia.93
GERD is the most common long-term AE of POEM. Emerging data suggest that although the incidence of post-POEM GERD is high, most patients respond to anti-secretory medications.91 In addition, the incidence of GERD may decrease with time due to remodeling of the gastroesophageal junction.26 Several new approaches have been suggested to address the issue of GERD after POEM. These include modification of POEM techniques (preservation of sling fibers), natural orifice transluminal endoscopic surgery (NOTES) fundoplication, and trans-oral incisionless fundoplication after POEM.94-98 Quality trials are required before confirming the efficacy of these methods in preventing or treating post-POEM GERD.
The EndoFLIP system has recently been introduced in clinical practice to predict the clinical outcomes of POEM in achalasia and refractory gastroparesis. It utilizes impedance planimetry to determine the DI and cross-sectional area of the gastroesophageal junction or pyloric sphincter. The current literature is divergent with regard to the utility of DI and cross-sectional area in predicting the outcomes of POEM and G-POEM in esophageal motility disorders and refractory gastroparesis, respectively.99,100 Therefore, future studies are required to determine the real-world utility of EndoFLIP in GI motility disorders.


Over the last decade, submucosal endoscopy has proven useful for a broad spectrum of GI diseases. Of note, submucosal endoscopy is an evolving field, and the certainty of evidence and efficacy varies across different indications in the GI tract. While the safety and efficacy of submucosal endoscopy have been consistent across the indications, the durability of response needs to be established for some indications, such as refractory gastroparesis and Zenker’s diverticulum. Additionally, evidence of its efficacy is limited in HD and esophageal strictures. With continued advancements in the field of submucosal endoscopy, there may be renewed interest in NOTES in the future. This is exemplified by recent reports of endoscopic transcolonic appendicectomy and transgastric cholecystectomy.101,102 In addition, endoscopists are likely to exploit the easy access to the third space or submucosal space when performing muscle biopsies to gain a better understanding of the pathophysiology of esophageal and gastric motility disorders.103-106 Similarly, safe access to the mediastinal and peritoneal spaces may potentially expand the indications of the ever-growing field of submucosal endoscopy.107,108


Submucosal endoscopy has been one of the most rewarding innovations in the field of therapeutic endoscopy in the recent era. Beginning with achalasia, the submucosal space is now being utilized to manage several GI diseases. While the utility of submucosal endoscopy has stood the test of time in esophageal motility disorders and SETs, its durability remains to be established in other conditions such as Zenker’s diverticulum and refractory gastroparesis. Additionally, novel techniques are required to reduce the incidence of GERD after POEM. Further studies are required to identify the predictors of response to G-POEM in patients with refractory gastroparesis. The potential of submucosal endoscopy to provide easy and safe access to the mediastinal and peritoneal spaces may open doors to novel indications and rejuvenate the interest of endoscopists in NOTES in the future.


Conflicts of Interest
The authors have no potential conflicts of interest.
Author Contributions
Conceptualization: ZN; Data curation: ZN, DNR; Formal analysis: ZN; Supervision: DNR; Validation: DNR; Visualisation: ZN, DNR; Writing–original draft: ZN; Writing–review & editing: DNR.

Fig. 1.
Current spectrum of submucosal endoscopy in gastrointestinal tract.
Fig. 2.
Technique of per-oral endoscopic myotomy in esophageal motility disorders. (A) Submucosal lifting injection using an injection needle. (B) Mucosal incision using a triangular knife. (C) Submucosal tunneling using a triangular knife. (D) Control of intraprocedural bleeding using coagulation forceps. (E) Selective circular (upper part) and full-thickness myotomy. (F) Closure of the mucosal incision with endoclips.
Fig. 3.
Submucosal tunneling with division of cricopharyngeal septum in a case of Zenker’s diverticulum. (A) Endoscopic image revealing the cricopharyngeal septum. (B) Submucosal lifting injection proximal to the septum. (C) Mucosal incision using an electrosurgical knife. (D) Submucosal tunneling along the diverticulum pouch. (E) Submucosal tunneling along the esophageal side and complete exposure of the septum. (F) Division of the cricopharyngeal septum using an electrosurgical knife. (G) Completion of cricopharyngeal myotomy. (H) Closure of mucosal incision with multiple endoclips.
Fig. 4.
Gastric per-oral endoscopic myotomy in a case of refractory gastroparesis. (A) Submucosal lifting injection 3 to 4 cm proximal to the pylorus. (B) Submucosal tunneling towards the pylorus. (C) Visualization of the pyloric sphincter. (D) Confirmation of extension of submucosal tunnel beyond the pyloric sphincter. (E) Execution of endoscopic pyloromyotomy. (F) Endoscopic appearance of the pyloric sphincter after pyloromyotomy. Courtesy by Harshal Mandavdhare (Associate Professor, Post Graduate Institute of Medical Education and Research, Chandigarh, India).
Fig. 5.
Submucosal tunneling endoscopic resection in a case of esophageal subepithelial tumor. (A) Endoscopic appearance of the mid-esophageal subepithelial lesion. (B) Submucosal lifting injection 2 to 3 cm above the subepithelial lesion. (C) Vertical mucosal incision using a triangular knife. (D) Submucosal tunneling along the presumed orientation of the subepithelial lesion. (E) Exposure of the subepithelial tumor. (F) Dissection of the tumor from surrounding attachments. (G) Retrieval of the tumor using a polypectomy snare. (H) Closure of the mucosal incision using endoclips.
Fig. 6.
Individualized approach to gastric subepithelial. Note the preferred location of gastric submucosal lesions for ESE and STER (from Lu et al. PLoS One 2015;10:e011987077). ESE, endoscopic submucosal excavation; STER, submucosal tunneling endoscopic resection.
Fig. 7.
Per-rectal endoscopic myotomy in a patient with Hirschsprung’s disease. (A) Submucosal lifting injection. (B) Transverse mucosal incision 1 to 2 cm above the anal verge. (C) Submucosal tunneling with arrows indicating the muscle layer. (D) Completion of submucosal tunneling. (E) Full-thickness myotomy. (F) Closure of the mucosal incision using endoclips. Courtesy by Mohan Ramchandani (Consultant Gastroenterologist, Asian Institute of Gastroenterology, Hyderabad, India).
Table 1.
Long-term outcomes of per-oral endoscopic myotomy in esophageal motility disorder
Study Country, study design n Age (yr) Type of motility disorder Reflux esophagitis (%) Clinical success (%) Follow-up (mo)
Guo et al. (2017)14 China, R 67 40.7±15.3 I 13, II 50, III 4 13.4 88.1 40.1±2.8
Hernández Mondragón et al. (2017)15 Mexico, R 65 47 (20–81) I 19, II 34, III 12 15.4 72 48
Teitelbaum et al. (2018)16 USA, R 36 54.5 (20–88) I 10, II 17, 13 79.3 65 (60–76)
Liu et al. (2020)17 China, R 1,538 40.3±14.5 I 466, II 964, III 108 22.6 92.9 42
Brewer Gutierrez et al. (2020)18 Multicenter, R 146 49.8±16 I 41, II 70, III 9 16.8 95.2 55 (49.9–60.6)
Podboy et al. (2021)21 USA, R 55 59.18±2.4 I 13, II 23, III 15, 3.6 72.7 47.3±13.8
US 2, EGJOO 1, DES 1
Nabi et al. (2021)23 India, R 74 43.5±16.09 III 53, DES 11, JHE 10 48.6 90.5 47.5 (2–77)
Onimaru et al. (2021)24 Japan, R 15 49.7±15.9 NR NR 73.3 ≥120
McKay et al. (2021)25 USA, P 100 57 (20–88) I 29, II 41, III 5, NR 79 72 (66–82)
Campagna et al. (2021)27 USA, R 100 53 I 27, II 58, III 16 33.3 88 55

Values are presented as mean±standard deviation or median (range).

R, retrospective; DES, diffuse esophageal spasm; EGJOO, esophagogastric junction outflow obstruction; NR, not reported; JHE, jackhammer esophagus; P, prospective; US, unspecified.

Table 2.
Outcomes of submucosal tunneling and division of the septum in cases of Zenker’s diverticulum
Study n Size (mm) Procedure time (min) Adverse events (%) Clinical success (%) Follow-up (mo)
Repici et al. (2020)42 20 17.5 13.8 0 100 12
Yang et al. (2020)43 75 31.3 52.4 6.7 92.0 9.7
Budnicka et al. (2021)44 22 30 48.8 13.6 90.9 3
Elkholy et al. (2021)45 24 40 61 0 95.8 10
Sanaei et al. (2021)46 32 29.4 47.7 12.5 96.7 5.5
Mittal et al. (2021)47 24 27 NR 16.7 90.9 5.7
Al Ghamdi et al. (2022)48 119 34.8 46.1 16.8 92.7 NR
Kahaleh et al. (2022)49 52 NR 42.5 9.6 92.0 3.4

NR, not reported.

Table 3.
Outcomes of gastric per-oral endoscopic myotomy in refractory gastroparesis
Study Study design n Age (yr) Etiology (%) Clinical success (%) Adverse events (%) Predictors of success or failure
Mekaroonkamol et al. (2019)64 Retrospective, single center 40 47.7±15.5 DG: 62.5 80.0 at 1 mo 7.5 Success: predominant nausea/vomiting and shorter duration of disease
NDG: 37.5 57.1 at 1 yr
70.0 at 1.5 yr
Gregor et al. (2021)65 Prospective, single center 52 48 (25–80) DG: 40.5 58.0 at 6 mo 5.8 Failure: longer duration of symptoms
NDG: 59.5 48.0 at 1 yr
Abdelfatah et al. (2021)66 Retrospective, single center 90 42.4±12.6 DG: 42.2 81.0 at 3–6 mo 4.4 Failure: high BMI and use of psychiatric medications
NDG: 57.8 69.1 at 1 yr
Ragi et al. (2021)67 Retrospective, multicenter 76 56 (43–64) DG: 34.2 65.8 at 1 yr 6 Success: high preoperative GCSI satiety subscale score
NDG: 65.8 Failure: high rate of gastric retention at 4 hours
Vosoughi et al. (2022)68 Prospective, multicenter 80 49.3±14.9 DG: 23.8 57.5 at 1 mo 6.2 Success: baseline GCSI Score >2.6 and baseline gastric retention >20% at 4 hours
NDG: 76.2 56.0 at 1 yr
Labonde et al. (2022)69 Prospective, multicenter 46 54±15.9 DG: 32.6 65.2 at 3 yr NR Success: cases with predictive score ≥2
NDG: 67.4

Values are presented as mean±standard deviation or median (range). DG, diabetic gastroparesis; NDG, non-diabetic gastroparesis; BMI, body mass index; GCSI, gastric cardinal symptom index; NR, not reported.

Table 4.
Recent updates and future directions on submucosal endoscopy in the gastrointestinal tract
Disease Procedure Update Future directions
Achalasia cardia POEM Short and long esophageal myotomy are equally effective in type I/II achalasia Long-term outcomes of POEM especially with reference to gastroesophageal reflux; modified techniques for prevention of GERD
Single dose of antibiotic prophylaxis may be sufficient before POEM
POEM is superior to PD and equivalent to HM at 2-years follow-up
Subepithelial tumors STER/POET Transesophageal resection of mediastinal cysts and extraluminal tumors is feasible Randomized comparison with endoscopic submucosal excavation, predictors of en-bloc resection
Gastroparesis G-POEM Outcomes of G-POEM are modest in refractory gastroparesis Long-term outcomes, utility of EndoFLIP and predictors of outcomes, randomized comparison with surgical pyloroplasty
Zenker’s diverticulum Z-POEM Variation in techniques (over the septum, Z-POEM+mucosotmy and hybrid Z-POEM) may improve technical and clinical outcomes Long-term outcomes of Z-POEM and comparative trials with flexible endoscopic myotomy
Others (Hirschsprung’s disease, esophageal strictures) PREM, POETRE Submucosal endoscopy may be a potential alternative to surgery in Hirschsprung’s disease and complete esophageal obstruction Long-term outcomes, comparison with surgery

POEM, per-oral endoscopic myotomy; PD, pneumatic dilatation; HM, Heller’s myotomy; GERD, gastroesophageal reflux disease; STER, submucosal tunneling endoscopic resection; POET, per-oral endoscopic tumor resection; G-POEM, gastric POEM; EndoFLIP, endoluminal functional lumen imaging probe; PREM, per-rectal endoscopic myotomy; POETRE, per-oral endoscopic tunneling for restoration of the esophagus.


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