Korean Journal of Gastrointestinal Endoscopy 1993;13(4): 713-718.
정상 대장내시경 검사시 점막 생검의 의의 ( The Significance of Mucosal Biopsy in Normal Colonoscopy )
김재선, 조은래, 권소영, 변관수, 박영태, 김진호, 김종극, 이창홍, 김철환, 원남희 (Jae Seon Kim, Eun Rae Jo, So Young Kwon, Kwan Soo Byun, Young Tae Bak, Jin Ho Kim, Jong Guk Kim, Chang Hong Lee, Chul Hwan Kim and Nam Hee Won)
Abstract
Many patients of gastroenterology clinics complain symptoms requiring colonic investigations. Radiological examinations may fail to detect early inflammatory bowel diseases and small neoplasms or polyps. And therefore colonoscopies are performed in preference to barium enema. Recently several reports raised a question regarding whether biopsy is necessary in a macroscopically normal colon. To determine what proportion of apparently normal colons is histologically abnormal, to measure the thickness of subepithelial basement membrane(SEBM) in normal colons, and to see whether the thiekness varies according to the different areas of the large bowel we prospectively analyzed 100 consecutive subjects with normal laboratory findings and normal mucosa on colonoscopy. Significant histologic abnormalities were not detected in all 100 cases. Thickness of SEBM (mean+SD) was 1.6+0.4 um at hepatic flexure, 1.6+0.4um at splenic flexure and 1.7+0.4 pm at sigmoid colon. The SEBM was significantly thicker at the sigmoid colon than at the hepatic flexure. Range of thickness of normal SEBM was 0.8 to 2.5 pm(mean+2SD). Maximum thickness of SEBM was 3 pm. The result of this study suggests that doing colonoscopic biopsies in all normal colons do not seem to be essential in Koreans yet.
PDF Links
Full text via DOI 
Download Citation 
