A Survey of Peri-Colonoscopy Management of Anti-Diabetic Medications

Article information

Clin Endosc. 2020;53(5):623-626

Publication date (electronic) : 2020 April 28

doi : https://doi.org/10.5946/ce.2020.021

Byeori Lee^,1,*, Deepanshu Jain^2,*, Michael Rajala²

¹Department of Internal Medicine, Albert Einstein Healthcare Network, Philadelphia, PA, USA

²Division of Gastroenterology, Department of Digestive Diseases and Transplantation, Albert Einstein Healthcare Network, Philadelphia, PA, USA

Correspondence: Byeori Lee Department of Internal Medicine, Albert Einstein Healthcare Network, 5501 Old York Road, Philadelphia, PA 19141, USA Tel: +1-215-456-8210, Fax: +1-215-455-1933, E-mail: leebyeor@einstein.edu

^*

These authors contributed equally to this study.

Received 2020 January 1; Revised 2020 March 21; Accepted 2020 March 27.

Over 14 million colonoscopies are performed annually in the United States [1]. The most well-recognized indication for colonoscopy is colorectal cancer (CRC) screening and surveillance. In addition, colonoscopy is widely used for the diagnostic examinations of symptoms (abdominal pain, rectal bleeding, or changes in bowel habits) and positive results of other CRC screening tests (positive fecal occult blood). Diabetes mellitus (DM) is among the most common illnesses in the United States. According to the most recent statistics, 23.1 million people or 7.2% of the United States population have been diagnosed with DM, with 95% of them being diagnosed with type 2 DM [2]. The prevalence of DM has increased over the past decades [3]. The percentage of adults with DM increased with age, reaching 12.7% among those aged 45–64 years and 20.8% among those aged 65 years or older. In other words, approximately 10%–20% of patients undergoing colonoscopy may have diabetes.

Adequate pre-procedure bowel preparation is key to the success of colonoscopy because poor preparation results in longer procedure times, lower detection rates of lesions, and a higher risk of complications [4,5]. Since bowel preparations and restrictions in diet for colonoscopy can affect blood glucose levels in diabetic patients, it is important to adjust anti-diabetic medications for the planned procedure. Unfortunately, there is no guideline for this adjustment, and different centers (and individual practitioners) have their self-made regimens based on the general principles of action of these medications. Not infrequently, diabetic patients present with hypoglycemia or hyperglycemia on the day of the procedure, which leads to a delay in starting the procedure on time [6]. Although this may be attributed to multiple factors such as instructions being too complex, patients forgetting verbal instructions over time (longer intervals between outpatient appointment and procedure day), or patients having poor control of their diabetes at baseline, we hypothesize that the lack of evidence-based recommendations leads to a lack of consensus which causes confusion and mismanagement at the patient level.

Through our research, we aimed to find real-world practices of gastroenterology providers in the management of anti-diabetic medications during the peri-colonoscopy period for type 2 DM patients.

We created a 20-question online survey using Google Survey to gather data on real-world practices of gastroenterology providers for the management of diabetes using anti-diabetic medications during the peri-colonoscopy period for type 2 DM patients. The first question of the survey established the title of the responder (attending physician, fellow-in-training, or nurse practitioner/physician assistant).

The rest of the questions were designed to ask anti-diabetic medication adjustments specific to six non-insulin medications and four insulin regimens for each meal on the day before and the day (morning) of colonoscopy. The six non-insulin medications included biguinades, sodium-glucose cotransporter-2 inhibitors, dipeptidyl peptidase 4 inhibitors, thiazolidinediones, sulfonylureas, and meglitinides. Four insulin regimens included long-acting, intermediate-acting, short-acting, and premixed insulins. Examples of common brand names were provided for each class of medications. For non-insulin medications, the responders were given options that included “do not take”, “take”, and “do not know”. For insulin regiments, the options included “do not take”, “decrease by half”, “take the usual dose”, and “do not know”. Because bowel preparation time and methods can vary depending on the time of the colonoscopies, we clarified in our survey that all the colonoscopies would be in the morning in this scenario.

The online survey was distributed to thirty-three providers including attending physicians, fellow physicians, or nurse practitioners/physician assistants who are routinely involved in planning colonoscopies at our medical center (Einstein Medical Center, Philadelphia, PA, USA). The answers from each provider were collected after 4 weeks. For each question, the percentages of the answers were calculated. Two expert endocrinologists were consulted to give best practice recommendations regarding the same medications that were included in the questionnaires. The collected answers were compared with the endocrinologists’ opinion. The percentages of the answers that were in agreement or disagreement with the endocrinologists’ opinions were calculated.

Here is the actual Google Survey link:

https://docs.google.com/forms/d/e/1FAIpQLSf6ihaIO1GtwsZXdoGa1js5wZJ741lU7uiC90XeOM0lJNM-NA/viewform?usp=sf_link

Among 33 providers, 24 providers (72.7%) answered the survey. Of them, 12/24 (50%) were attending physicians, 6/24 (25%) were fellows-in-training, and 6/24 (25%) were nurse practitioners/physician assistants. The calculated percentages and cumulative numbers for responses specific to each medication and meal are summarized in Tables 1, 2, and 3. The answers were compared with the endocrinologists’ opinion and the percentages in agreement and disagreement were calculated. The answers with the footnote represent the appropriate answers recommended by the endocrinologists.

Table 1.

Non-Insulin Medication Management on the Day before a Colonoscopy

Table 2.

Insulin Regimen Management on the Day before a Colonoscopy

Table 3.

Non-Insulin Medication and Insulin Regimen Management in the Morning of a Colonoscopy

Irrespective of indication, adequate pre-procedure bowel preparation is key to successful colonoscopy. Poor preparation results in longer procedure times, lower detection rates of lesions, and a higher risk of complications [4,5]. Restrictions in diet the day before colonoscopy and fasting after midnight are an integral part of any bowel preparation regimen regardless of the laxative agent used. In addition, patients with type 2 DM need recommendations pertinent to the management of their anti-diabetic medications in the peri-colonoscopy period. Unfortunately, no evidence-based guidelines exist. Even though there are several recommendations and guidelines available for perioperative management of anti-diabetic medications, those guidelines are not applicable to peri-colonoscopy management due to the unique nature of bowel preparation and dietary restrictions [7-9]. A recent review by Hochberg et al. suggested instructions for antihyperglycemic medications precolonoscopy [6]. The recommendations in this review are similar to the expert recommendations we used for our study but not exactly the same, which again highlights the need for actual data to accurately come up with evidence-based practice recommendations.

The aim of this study was to find real-world practices of gastroenterology providers in the management of anti-diabetic medications in the peri-colonoscopy period for type 2 DM patients. As presented in Tables 1, 2 and 3, there is a great disparity amongst gastroenterology providers and also when compared to endocrinologist recommendations. For medications that are less familiar, there were more “do not know” answers suggesting the providers do not feel comfortable making decisions regarding these newer or uncommonly used medications. Unfortunately, for the most common medications like metformin and long-acting insulin, the majority was in disagreement with the endocrinologists’ opinion. For metformin, most gastroenterology providers chose “take” as the answer, likely due to the well-established lack of associated hypoglycemia. However, the cessation of metformin within 48 hours before a surgery or procedure is recommended due to the potential risk of lactic acidosis sue to possible bleeding, dehydration, or contrast-induced acute kidney injury [9]. During the colonoscopy, the expected bleeding risk is low and no contrast is used. However, due to bowel preparation, there is a risk of dehydration and electrolyte imbalance. For this reason, endocrinologists recommended stopping metformin the day before and morning of the colonoscopy. For patients who are fasting, gastroenterology providers were reluctant to use the full amount of long-acting insulin. But for long-acting insulin, endocrinologists recommended using the full-dose the day before the colonoscopy. On the day of the colonoscopy, there was a better agreement between the providers and endocrinologists. However, there was no consensus. In addition, it was important to note that there was full agreement between the two endocrinologists from two different tertiary centers.

Our study comes with the limitations of being a single-center experience with a limited number of responders (twenty-four providers). Moreover, we do not have data on hypoglycemic or hyperglycemic events on the day of colonoscopy limiting our ability to conclude if disparities in the recommendations for the management of anti-diabetic medications in the peri-colonoscopy period actually have an impact on patient outcomes. Despite the limitations, our study identifies a clinically important question that will need collaborative effort from professionals in the fields of endocrinology and gastroenterology to develop best practice recommendations for the management of anti-diabetic medications for type 2 DM patients undergoing colonoscopy.

Our findings indicate a marked disparity amongst gastroenterology providers (attendings, fellows, and nurse practitioners/physician assistants) with regard to endocrinologist recommendations for the management of anti-diabetic medications in the peri-colonoscopy period. It also shows a lack of familiarity of gastroenterologists with newer anti-diabetic medications. A lack of consensus can lead to confusion and mismanagement at the patient level, which can result in clinically significant hypoglycemic and hyperglycemic events. There is an unmet need for best practice recommendations for the management of anti-diabetic medications in the peri-colonoscopy period.