Korean Journal of Gastrointestinal Endoscopy 2007;34(4): 193-199.
소아 크론병의 임상적 특징과 경과
이나영·박재홍*
부산성모병원 소아과, *부산대학교 의과대학 소아과학교실
Clinical Features and Course of Crohn Disease in Children
Na Young Lee, M.D. and Jae Hong Park, M.D.*
Department of Pediatrics, Busan St. Mary's Medical Center, *Pusan National University Hospital, Busan, Korea
Abstract
Background/Aims: The aim of this study was to evaluate the clinical features and course of Crohn disease (CD) in children. Methods: The medical records of 30 patients diagnosed with CD between January 1996 and December 2005 were reviewed retrospectively. Results: The actual number of newly diagnosed patients with CD has increased during the 8-year period. The male/female ratio was 2：1 and the mean age at diagnosis was 10.6⁑4.3 years. The major symptoms of CD at diagnosis were abdominal pain (79.2%), weight loss (54.2%), perianal lesion (54.2%), diarrhea (45.8%), hematochezia (41.7%), anemia (29.2%), and fever (23.3%). The disease location of CD was the small bowel in 33.3%, the large bowel in 12.5% and both the small and large bowel in 54.2%. Granuloma was found in 54.2% of patients. The relapse rate of CD in the group with a higher pediatric Crohn disease activity index (PCDAI) at diagnosis (≥30) was higher than in the group with a lower PCDAI (＜30). The cumulative relapse rates of the patients with granuloma were 30.2% within 1 year and 53.8% within 5 years after the diagnosis. Conclusions: The incidence of CD in children appears to be increasing. Granuloma formation and a higher score of the PCDAI are associated with a more severe disease course. Pediatric CD may have a somewhat different clinical presentation from older-onset CD. (Korean J Gastrointest Endosc 2007;34:193199)
PDF Links
Full text via DOI 
Download Citation 
