| 저용량 삼제요법과 표준용량 삼제요법에서의 Helicobacter pylori 제균율 비교 |
| 백우현·김연주·김인경·이재경·이창현·정고은·홍경섭·박영수*·황진혁*·김진욱*·정숙향*·김나영*·이동호*·정현채·송인성 |
| 서울대학교 의과대학 내과학교실, 간연구소, *분당서울대학교병원 내과 |
| Comparison of the Eradication Rates of One-week Low-dose Triple Therapy with Standard-dose Triple Therapy for Helicobacter pylori Infection |
| Woo Hyun Paik, M.D., Youn Joo Kim, M.D., In Kyoung Kim, M.D., Jae Kyoung Lee, M.D., Chang Hyun Lee, M.D., Goh Eun Chung, M.D., Kyung Sup Hong, M.D., Young Soo Park, M.D.*, Jin-Hyeok Hwang, M.D.*, Jin Wook Kim, M.D.*, Sook Hyang Jung, M.D.*, Nayoung Kim, M |
| Department of Internal Medicine and the Liver Research Institute, Seoul National University Hospital, Seoul, *Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea |
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| Abstract |
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Background/Aims:
We can expect to reduce costs and decrease adverse events by using low-dose triple therapy for H. pylori eradication. However, the efficacy of low-dose triple therapy for Koreans is questionable. In this study, we compared the efficacy of low-dose triple therapy with standard-dose triple therapy.
Methods:
We enrolled 480 patients who were diagnosed as suffering with H. pylori infection via endoscopy with biopsy or CLO testing. Thirty patients were excluded due to malignancy or having undergone previous antibiotics medication. Two hundred and eighty patients received standard-dose triple therapy (pantoprazole 40 mg b.d, amoxicillin 1,000 mg b.d., and clarithromycin 500 mg b.d.), and 170 patients received low-dose triple therapy (pantoprazole 40 mg b.d., amoxicillin 750 mg b.d., and clarithromycin 250 mg b.d.). Eradication was evaluated 4∼6 weeks after administering the medication.
Results:
The H. pylori eradication rate was 77.9% in the standard-dose group, and 74.7% in the low-dose group. There was no significant difference in the H. pylori eradication rate between the two groups (p=0.444). The adverse events were significantly more frequent in the standard-dose group. One patient each in both groups discontinued medication because of an adverse event.
Conclusions:
The efficacy of low-dose therapy is similar to standard-dose therapy, and the adverse events are less frequent with low-dose therapy. This suggests that low-dose therapy would be preferred when considering the cost- benefit and low rate of adverse drug events. |
| Key Words:
Helicobacter pylori, Eradication, Low dose, Triple therapy |
| 주요어:
Helicobacter pylori, 삼제요법, 제균, 저용량, 부작용 |
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