Korean Journal of Gastrointestinal Endoscopy 1996;16(6): 1001-1007.
증례 : 식도 위장관 ; 원발성경화성담관염 (原發性硬化性膽管炎) 을 동반한 궤양성대장염 (潰梁性大腸炎) 환자 1예 ( Case Reports : Esophagus , Stomach & Intestine ; A Case of Primary Sclerosing Cholangitis with Ulcerative Colitis )
정규원, 선희식, 박두호, 최규용, 박수헌, 한준열, 조세현, 한원희, 강창석 (Kyu Won Chung, Hee Sik Sun, Doo Ho Park, Kyu Yong Choi, Soo Heon Park, Joon Yeol Han, Se Hyun Cho, Won Hee Han and Chang Suk Kang)
Abstract
Sclerosing cholangitis is cholestatic disease, characterized by progressive fibrotic inflammation and obliteration af intrahepatic bile ducts and extrahepatic bile ducts and sometimes associated with ulcerative colitis. The pathogenesis of this disease is not understood well. In this disease, however, have been proposed infectious agent, endotoxin of bacteria and immunological event. In Europe and U.S.A., the incidence of sclerosing cholangitis associated with ulcerative colitis was between 2,4 and 4.0 percent. The association is strongest in patients with pancolitis, with a prevalenee of 5.5 percent, compared with patients with disease confined to the distal colon, with a prevalence of 0.5 percent. But, in Korea, it has not been reported sclerosing cholangitis associated with ulcerative colitis. A 30-year old man was diagnosed as an ulcerative colitis 9 years ago and has been followed up, intermittently. Recently, he has experienced hematochezia and dizziness. Colonoscopy showed active ulcerative colitis(pancolitis), blood chemistry elevated alkaline phosphatase and y-GTP. ERCP and liver biopsy specimen revealed sclerosing cholangitis. we concluded that this case was a sclerosing cholangitis as a complication of ulcerative colitis and the first case report of primary sclerosing cholangitis with ulcerative colitis in Korea, Hence, we reported a case of primary sclerosing cholangitis with ulcerative colitis with a review of literatures. (Korean J Gastrointest Endosc 16: 1001-1o07, 1996)
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