Korean Journal of Gastrointestinal Endoscopy 2001;23(4): 207-212.
요소호기 검사로 평가한 치료 기간에 따른 Helicobacter pylori 제균율의 분석 - OAC 7 , 10 , 14 일간 병합요법의 비교 - ( Analysis of Eradication Rate of Helicobacter pylori According to Treatment Duration by Using 13C - urea Breath Test - Comparison of OAC 7 , 10 , 14 days regimen - )
조영직(Young Jig Cho),전훈재(Hoon Jae Chu),김성태(Sung Tae Kim),고동욱(Dong Wook Koh),박재홍(Jae Hong Park),박동규(Dong Kyu Park),박철희(Chul Hee Park),이성준(Sung Joon Lee),진윤태(Yoon Tae Jeen),이홍식(Hong Sik Lee),엄순호(Soon Ho Um),이상우(Sang Woo Lee),최재현(Jai Hyun Choi),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hai Hyun)
Abstract
Background/Aims: Efficacy of triple therapy with omeprazole, amoxicillin, and clarithromycin (OAC) for helicobacter pylori (H. pylori) varies among different geographic regions and patient populations. And, there is no full con sensus on how long this treatment should be maintained. We assessed the efficacy of the OAC regimen according to the treatment duration (7, 10 or 14 days) using 13C-urea breath test (13C-UBT). Methods: Two hundred fifty five H. pylori positive patients with peptic ulcer were randomly assigned to a OAC (omeprazole 20 mg b.d., amoxicilln 1.0 g b.d.) . Eradication of H. pylori was assessed by 13C-UBT 4 weeks after the completion of the completion of therapy. Results: 140 male and 115 female (mean age, 51.3) patients were enrolled. The overall eradication rate of H. pylori in each group was significantly higher in OAC 14 days regimen than OAC 7 and 10 days regimen (91.9% in OAC 14 days, 74.4% in OAC 7 days, and 80.2% in OAC 10 days, respectively, p<0.05). Conclusions: The overall eradication rate of H. pylori was highest in OAC 14 days regimen in our study. We have found significant differences in eradication rates with previous reports, using CLO and histology, in Korea. Thus, further studies focusing on the treatment period may be warranted. (Korean J Gastrointest Endosc 2001;23:207-212)
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