Korean J Gastrointest Endosc > Volume 29(3); 2004 > Article
Korean Journal of Gastrointestinal Endoscopy 2004;29(3): 137-141.
골수이식 후 발생한 위장관 이식편대숙주병: 조직학적 검사로 확진된 7예
김경희·김영호·김지향·김정환·심상군·손희정·이풍렬·김재준·백승운·이종철
성균관대학교 의과대학 삼성서울병원 내과학교실
Intestinal Graft-Versus-Host Disease after Bone Marrow Transplantation: 7 Cases Proven by Histopathologic Diagnosis
Kyung Hee Kim, M.D., Young-Ho Kim, M.D., Ji Hyang Kim, M.D., Jeong Hwan Kim, M.D., Sang Goon Shim, M.D., Hee Jung Son, M.D., Poong-Lyul Rhee, M.D., Jae Jun Kim, M.D., Seung Woon Paik, M.D. and Jong Chul Rhee, M.D.
Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Abstract
Graft-versus-host disease (GVHD) is the major cause of morbidity or mortality after marrow transplantation. The intestinal involvement of GVHD is associated with high graft failure. It is usually difficult to diagnose gastrointestinal (GI) GVHD because symptom is nonspecific, and diagnostic criteria in endoscopic and histologic findings lack the gold standard. We reviewed 7 patients with GI GVHD proven by endoscopic biopsy from September 1999 to June 2003. The common GI symptoms at the time of endoscopy were diarrhea and abdominal pain. Four patients were acute GVHD, two acute and chronic GVHD, and one chronic GVHD. The interval from bone marrow transplantation to GVHD diagnosis by histological examination varied from 18 days to 259 days. The skin was involved in 5 patients. Two cases showed normal endoscopic finding. From these results, endoscopic biopsy is a essential tool in evaluating patients with GI complaints after bone marrow transplantation. (Korean J Gastrointest Endosc 2004;29:137⁣141)
Key Words: Intestinal graft-versus-host disease, Marrow transplantation
주요어: 위장관 이식편대숙주 병, 골수이식
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