Colonic irrigation is a procedure in which large quantities of liquids are infused into the colon via the rectum through a tube, in an effort to wash away and remove fecal materials. Liquids mostly used in colonics include water and coffee. This procedure has been performed generally in the alternative medicine community and becomes more popular in recent years. However, physicians criticize its potential hazards by insisting that there are not of any scientifically proven health benefit of this procedure. With the current popularity of colonic irrigation, it is important to investigate the adverse effect of colonic irrigation which has not been known or published yet. We report a case of 56 years old female with colonic injury after colonic irrigation. (Korean J Gastrointest Endosc 2005;31:175179)