Background
/Aims: Obscure gastrointestinal bleeding (OGIB) is defined as recurrent bleeding for which no source has been identified by routine endoscopic and contrast studies. This study was performed to determine the utility of capsule endoscopy in patients with OGIB. Methods: This retrospective study included 21 patients with GIB which were not identified by esophagogastroduodenoscopy and colonoscopy. Those were sixteen patients with overt OGIB (including 6 ongoing overt bleeding) and five with occult OGIB. All underwent capsule endoscopy with Given M2A video capsule system. Results: Definite bleeding of small intestine were identified in 9 of 21 patients (42.9%) and 8 of 9 patients presenting as overt OGIB (50.0%, 8/16). Additionally, 5 of 6 patients with ongoing bleeding on the day of capsule endoscopy were found to have the lesion in small intestine (83.3%, 5/6). Ulcers were found in 6 patients, diverticulitis in 2 patients, and a tumor in 1 patients. Conclusions: Capsule endoscopy, providing a good visualization of small intestine, is safe and well tolerated. Capsule endoscopy is an useful diagnostic tool for OGIB, especially for ongoing overt bleeding, and can guide the subsequent therapy and expand diagnostic yield in OGIB. (Korean J Gastrointest Endosc 2005;31:140146)