Korean J Gastrointest Endosc > Volume 41(4); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;41(4): 196-200.
십이지장 위화생의 발생에 영향을 미치는 십이지장의 임상병리학적 소견
장 태 정
동국대학교 의과대학 병리학교실
Clinicopathologic Features of the Duodenum Related to the Genesis of Duodenal Gastric Metaplasia
Tae Jung Jang, M.D.
Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea

It has been suggested that gastric metaplasia in the duodenum is prerequisite for duodenal ulcer. The aim of this study was to investigate the role of clinicopathologic parameters of the duodenum such as endoscopic diagnosis, pathologic findings and Helicobacter pylori (H. pylori) infection on the development of gastric metaplasia.
Endoscopic records as well as pathologic findings of 390 patients were reviewed. The degree of gastric metaplasia in duodenum was evaluated. H. pylori infection was determined by immunohistochemical staining.
The degree of gastric metaplasia was higher in duodenal ulcers and hyperplastic duodenal polyps than in chronic duodenitis. The degree of gastric metaplasia was closely related to severe acute inflammation, mild chronic inflammation and H. pylori infection in duodenum. Duodenal ulcers showed higher acute inflammation and a higher incidence of H. pylori infection than hyperplastic polyps and chronic duodenitis.
Gastric metaplasia in duodenal ulcers may be related to duodenal inflammation and H. pylori infection, whereas in hyperplastic polyps gastric metaplasia may occur by another mechanism. (Korean J Gastrointest Endosc 2010;41:196-200)
Key Words: Helicobacter pylori, Duodenal ulcer, Gastric metaplasia
주요어: H. pylori, 십이지장 궤양, 십이지장 위화생
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