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Korean J Gastrointest Endosc > Volume 28(4); 2004 > Article
Korean Journal of Gastrointestinal Endoscopy 2004;28(4): 168-172.
대장암과 Amidated Gastrin: Helicobacter pylori 감염 및위축성 위염과의 상관관계
정정환·김영호·이 혁·손주익·김흥업·김홍주·손희정·이풍렬·김재준·이종철
성균관대학교 의과대학 삼성서울병원 소화기내과
Colon Cancer and Amidated Gastrin: Correlation with AtrophicGastritis and Helicobacter
Chung Hwan Chung, M.D., Young-Ho Kim, M.D., Hyuk Lee, M.D., Ju Ik Sohn, M.D.,Heung Up
Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University, School of
Abstract

Background/Aims:
It has recently been reported that non-amidated gastrin is associated with the development of colon cancer. However it is not known whether amidated gastrin, atrophic gastritis, and the status of Helicobacter pylori (H. pylori) infection are related to colon cancer. The aims of this study were to determine whether plasma level of amidated gastrin is elevated in patients with colon cancer compared with controls and to determine whether H. pylori infection and/or atrophic gastritis affect the relationship between amidated gastrin and colon cancer.
Methods:
Twenty-two patients with colon cancer and twenty-two controls were enrolled in this study and their plasma amidated gastrin titers were measured by 125I radioimmunoassay. H. pylori infection was determined by histology. The degree of mucosal atrophy was determined by Sidney classification.
Results:
Amidated gastrin levels were not different between the patients with colon cancer and controls. The status of H. pylori infection did correlate with amidated gastrin levels. Antral mucosal atrophy was not also correlated with amidated gastrin levels, but there was a tendency (p=0.074).
Conclusions:
Amidated gastrin is not related to the development of colon cancer. (Korean J Gastrointest Endosc 2004;28:168⁣172)
Key Words: Colon cancer, Amidated gastrin, Atrophic gastritis, Helicobacter pylori
주요어: 대장암, Amidated gastrin, 위축성 위염, Helicobacter pylori
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