| 신경섬유종증의 동반 없이 발생한 단발성 결장 신경섬유종 1예 |
| 김경옥ㆍ장병익ㆍ문희정ㆍ이상훈ㆍ이준영ㆍ이규형ㆍ이시형ㆍ박윤선ㆍ최재원ㆍ은종렬ㆍ김태년ㆍ이헌주 |
| 영남대학교 의과대학 내과학교실 |
| A Solitary Colonic Neurofibroma in a Patient without Neurofibromatosis |
| Kyeong Ok Kim, M.D., Byung Ik Jang, M.D., Hee Jung Moon, M.D., Sang Hoon Lee, M.D., Jun Young Lee, M.D., Kyu Hyung Lee, M.D., Si Hyung Lee, M.D., Youn Sun Park, M.D., Jae Won Choi, M.D., Jong Ryul Eun, M.D., Tae Nyun Kim, M.D. and Heon Ju Lee, M.D. |
| Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea |
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| Abstract |
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Neurofibromas are usually manifestations of neurofibromatosis type 1 (Nf1). There are usually multiple lesions on presentation. Solitary neurofibromas of the colon are extremely rare. A 34-year-old Asian male came to our hospital for non-specific findings, except for a complaint of loose stools for 2 months. A colonoscopy was performed. A sessile polyp 0.4 cm in diameter was detected at the sigmoid colon. Microscopically, a biopsy from the polyp showed proliferation of spindle cells in the mucosa, myxoid changes and infiltration of inflammatory cells. Immunohistochemical staining was positive for S-100 protein. The above morphological and immunohistochemical characteristics were consistent with a diagnosis of a neurofibroma. Only 13 cases of isolated colonic neurofibromatosis without Nf1 have been documented in the literature. We report this case as an isolated neurofibroma of the colon is even a rarer manifestation, and only three cases have been published in the clinical literature. (Korean J Gastrointest Endosc 2008;36:44-47) |
| Key Words:
Neurofibromatosis, Neurofibroma, Colon, S-100 protein |
| 주요어:
신경 섬유종증, 결장 신경 섬유종, S-100단백 |
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