Korean J Gastrointest Endosc > Volume 40(3); 2010 > Article
Korean Journal of Gastrointestinal Endoscopy 2010;40(3): 175-180.
Cyclophosphamide 단일 화학요법으로 치유된 위 변연부 B 세포 림프종 2예
배영석ㆍ이광재ㆍ김동완ㆍ홍준호ㆍ윤정빈ㆍ배상훈ㆍ이진숙*ㆍ송철수
좋은삼선병원 내과, *병리과
Two Cases of Gastric Marginal Zone B Cell Lymphoma Treated with a Single Agent Chemotherapy
Young Seok Bae, M.D., Kwang Jae Lee, M.D., Dong Wan Kim, M.D., Jun Ho Hong, M.D., Jung Bin Yoon, M.D., Sang Hoon Bae, M.D., Jin Suk Lee, M.D.* and Chul Soo Song, M.D.
Departments of Internal Medicine and *Pathology, Good Samsun Hospital, Busan, Korea
Abstract
Gastric marginal zone B cell lymphoma of the MALT type (MALT lymphoma) is usually accompanied by a Helicobacter pylori (H. pylori) infection. Most gastric MALT lymphomas regress after the eradication of H. pylori. Therefore, H. pylori eradication therapy is an effective first-line treatment for gastric MALT lymphoma. A second-line treatment for patients who fail to respond to eradication therapy, including radiotherapy and chemotherapy, produces a good response and survival rate. We encountered 2 cases of H. pylori eradication-resistant gastric MALT lymphoma, which were treated with cyclophosphamide monotherapy. A complete response was obtained in both cases after a treatment duration of 3 months and remission continued for 15 and 18 months, respectively. Treatment-related toxicity was mild. Oral monochemotherapy might be an alternative, effective and safe treatment modality for patients with gastric MALT lymphoma who are resistant to H. pylori eradication therapy. (Korean J Gastrointest Endosc 2010;40:175-180)
Key Words: Stomach, Marginal zone, MALT, Cyclophosphamide
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