| Cyclophosphamide 단일 화학요법으로 치유된 위 변연부 B 세포 림프종 2예 |
| 배영석ㆍ이광재ㆍ김동완ㆍ홍준호ㆍ윤정빈ㆍ배상훈ㆍ이진숙*ㆍ송철수 |
| 좋은삼선병원 내과, *병리과 |
| Two Cases of Gastric Marginal Zone B Cell Lymphoma Treated with a Single Agent Chemotherapy |
| Young Seok Bae, M.D., Kwang Jae Lee, M.D., Dong Wan Kim, M.D., Jun Ho Hong, M.D., Jung Bin Yoon, M.D., Sang Hoon Bae, M.D., Jin Suk Lee, M.D.* and Chul Soo Song, M.D. |
| Departments of Internal Medicine and *Pathology, Good Samsun Hospital, Busan, Korea |
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| Abstract |
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Gastric marginal zone B cell lymphoma of the MALT type (MALT lymphoma) is usually accompanied by a Helicobacter pylori (H. pylori) infection. Most gastric MALT lymphomas regress after the eradication of H. pylori. Therefore, H. pylori eradication therapy is an effective first-line treatment for gastric MALT lymphoma. A second-line treatment for patients who fail to respond to eradication therapy, including radiotherapy and chemotherapy, produces a good response and survival rate. We encountered 2 cases of H. pylori eradication-resistant gastric MALT lymphoma, which were treated with cyclophosphamide monotherapy. A complete response was obtained in both cases after a treatment duration of 3 months and remission continued for 15 and 18 months, respectively. Treatment-related toxicity was mild. Oral monochemotherapy might be an alternative, effective and safe treatment modality for patients with gastric MALT lymphoma who are resistant to H. pylori eradication therapy. (Korean J Gastrointest Endosc 2010;40:175-180) |
| Key Words:
Stomach, Marginal zone, MALT, Cyclophosphamide |
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