Health-Care Utilization and Complications of Endoscopic Esophageal Dilation in a National Population

Abhinav Goyal; Kshitij Chatterjee; Sujani Yadlapati; Shailender Singh

doi:10.5946/ce.2016.155

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Original Article Health-Care Utilization and Complications of Endoscopic Esophageal Dilation in a National Population: Abhinav Goyal^1,, Kshitij Chatterjee², Sujani Yadlapati¹, Shailender Singh³; Clinical Endoscopy 2017;50(4):366-371.
DOI: https://doi.org/10.5946/ce.2016.155
Published online: March 17, 2017

¹Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USA

²University of Arkansas for Medical Sciences, Little Rock, AR, USA

³Department of Gastroenterology, University of Nebraska Medical Center, Omaha, NE, USA

Correspondence: Abhinav Goyal Department of Internal Medicine, Einstein Medical Center, 5501 Old York Road, Suite 363 (Klein Building), Philadelphia, PA 19141, USA Tel: +1-215-456-8520, Fax: +1-215-455-1933, E-mail: goyalabh@einstein.edu

• Received: November 12, 2016 • Revised: January 19, 2017 • Accepted: January 19, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
NOTES
REFERENCES

See letter "Safe and Proper Management of Esophageal Stricture Using Endoscopic Esophageal Dilation" in Volume 50 on page 309.

Abstract

Background/Aims
Esophageal stricture is usually managed with outpatient endoscopic dilation. However, patients with food impaction or failure to thrive undergo inpatient dilation. Esophageal perforation is the most feared complication, and its risk in inpatient setting is unknown.
Methods
We used National Inpatient Sample (NIS) database for 2007–2013. International Classification of Diseases, 9th revision, Clinical Modification (ICD-9-CM) codes were used to identify patients with esophageal strictures. Logistic regression was used to assess association between hospital/patient characteristics and utilization of esophageal dilation.
Results
There were 591,187 hospitalizations involving esophageal stricture; 4.2% were malignant. Endoscopic dilation was performed in 28.7% cases. Dilation was more frequently utilized (odds ratio [OR], 1.36; p<0.001), had higher in-hospital mortality (3.1% vs. 1.4%, p<0.001), and resulted in longer hospital stays (5 days vs. 4 days, p=0.01), among cases of malignant strictures. Esophageal perforation was more common in the malignant group (0.9% vs. 0.5%, p=0.007). Patients with malignant compared to benign strictures undergoing dilation were more likely to require percutaneous endoscopic gastrostomy or jejunostomy (PEG/J) tube (14.1% vs. 4.5%, p<0.001). Palliative care services were utilized more frequently in malignant stricture cases not treated with dilation compared to those that were dilated.
Conclusions
Inpatient endoscopic dilation was utilized in 29% cases of esophageal stricture. Esophageal perforation, although infrequent, is more common in malignant strictures.
Keywords: Esophageal stenosis; Endoscopic dilation; Inpatients; Percutaneous endoscopic gastrostomy; Malignant stricture

INTRODUCTION

Esophageal stricture is an important cause of dysphagia in adults, and can result in considerable morbidity and mortality. Esophageal strictures can result from both benign and malignant processes. Benign strictures are most commonly related to gastroesophageal reflux disease followed by other etiologies such as eosinophilic esophagitis, radiation-induced, postsurgical, or caustic ingestion [1,2]. Malignant strictures, however, usually result from intrinsic processes such as esophageal carcinoma [3].

The goals of therapy for esophageal strictures are relief of dysphagia and prevention of stricture recurrence [4]. Most cases of esophageal strictures are managed with elective outpatient endoscopic dilation. However, some patients present with food impaction or failure to thrive owing to severe dysphagia, undergo urgent inpatient endoscopic dilation. Esophageal perforation is the most feared complication of dilation, and its risk in this setting (i.e., urgent/inpatient setting) is not well described. Although the incidence of perforation is low, the mortality associated with dilation approaches 20% [5].

The aim of this study was to explore the health-care utilization of endoscopic dilation for the treatment of esophageal strictures in the inpatient setting, and to define the rate of complications and outcomes of this procedure.

MATERIALS AND METHODS

Sample

We used the National Inpatient Sample (NIS) database, which was constructed as part of the Healthcare Cost Utilization Project by the Agency of Healthcare Research and Quality for the years 2007 through 2013 [6]. NIS is the largest all-payer inpatient database in the United States. It is a 20% stratified sample of all discharges in a calendar year. Manufacturer-provided sampling weights were used to produce national estimates from the data.

International Classification of Diseases, 9th revision, Clinical Modification (ICD-9-CM) code 530.3 (stricture and stenosis of esophagus) was used to identify all patients with esophageal strictures. We then used ICD-9-CM codes 150.0, 150.1, 150.2, 150.3, 150.4, 150.5, 150.8, 150.9, 230.1, and V10.03 to identify patients with malignant strictures. Similarly, ICD-9-CM procedure code 42.92 was used to identify patients who underwent endoscopic esophageal dilation during hospitalization. All patients aged <18 years, or with missing age or sex information were excluded from analysis.

Statistical analysis

The demographic characteristics and outcomes were calculated for all patients who underwent esophageal dilation for esophageal stricture and its subgroups (benign and malignant). The chi-square, Mann-Whitney, and independent-samples t-tests were used to compare for statistical significance. Multivariate logistic regression analysis was used to assess the impact of individual patient and hospital characteristics on the utilization of endoscopic dilation among patients with esophageal strictures. We used age groups (18–39, 40–64, and ≥65 years), sex, race, and the Charlson comorbidity index for patient characteristics in the regression model. For hospital characteristics, we included the hospital bed size, hospital location (urban vs. rural), teaching status of the hospital, weekend versus weekday admission, and hospital region. The Charlson comorbidity index is a validated tool used for adjusting for comorbidities among databases based on ICD-9-CM codes. We used a modification of the Charlson index to exclude the cancer comorbidity from the original index, given that esophageal cancer was an independent variable in our regression model.

A similar model was also used to assess for utilization of palliative care services among patients with malignant strictures. SPSS 23.0 (SPSS Inc., Chicago, IL, USA) and Stata 13.0 (StataCorp, College Town, TX, USA) were used for all statistical analyses. Institutional review board approval was not required as NIS is a de-identified national database.

RESULTS

Between 2007 and 2013, there were a total of 591,187 hospitalizations involving esophageal strictures, 4.2% of which were associated with esophageal malignancy (i.e., malignant stricture). Endoscopic dilation was performed in 28.7% cases of stricture. On subgroup analysis, however, endoscopic dilation was more frequently utilized in patients with malignant stricture than in patients with benign stricture stricture (31.9% vs. 28.6%, p<0.001). Even after adjusting for various hospital and patient characteristics by using multivariate logistic regression analysis, endoscopic dilation remained more frequently utilized among patients with malignant stricture (odds ratio [OR], 1.36; confidence interval [CI], 1.27–1.46; p<0.001).

The demographic characteristics, hospital characteristics, and outcomes of patients with esophageal stricture who underwent endoscopic dilation are shown in Table 1. Men constituted a significant majority of patients with malignant stricture (72.7%), in contrast to the benign stricture group (41.2% male patients). Caucasians were the predominant racial group among both subgroups. Although most patients in both groups had a higher comorbidity burden (Charlson index 2), the malignant stricture subgroup had a significantly higher proportion in this category (75.4% vs. 44.9%, p<0.001).

The overall in-hospital or periprocedural mortality (mortality during the hospitalization when the procedure was performed was presumed to be directly or indirectly related to the procedure) was 1.5%, and the median length of stay was 4 days. Patients with malignant strictures had a higher in-hospital mortality (3.1% vs. 1.4%, p<0.001) and a longer hospital stay (5 days vs. 4 days, p=0.01). However, the length of stay for patients who were discharged alive to a non-facility location was 4 days for both groups. The incidence of esophageal perforation was very low in both groups, although it was slightly higher in the malignant group (0.9% vs. 0.5%, p=0.007). The rate of esophageal perforation according to various hospital characteristics is shown in Fig. 1. Patients with malignant stricture undergoing dilation were also significantly more likely to require percutaneous endoscopic gastrostomy or jejunostomy (PEG/J) tube placement (14.1% vs. 4.5%, p<0.001) during the same hospitalization compared with those with benign stricture. Hospital characteristics, PEG/J utilization, and palliative care utilization (encounter with the palliative care team) were also calculated for all patients with malignant stricture, including those not undergoing dilation, and are shown in Table 2. Overall, palliative care was utilized in 5.5% cases of malignant stricture. It was utilized significantly more often in patients not undergoing stricture dilation (6.6% vs. 3.1%, p<0.001). Even after adjusting for all patient and hospital characteristics by using multivariate regression analysis, as described above, palliative care remained significantly underutilized among those undergoing dilation compared with those who were not dilated (OR, 0.50; CI, 0.36–0.69; p<0.001).

DISCUSSION

Esophageal dilation is a fairly common technique used for the treatment of benign and malignant esophageal strictures. However, its utilization in the inpatient setting is not well known. In our study, esophageal dilation was utilized in 28% of cases of esophageal stricture. Moreover, it was seen that strictures necessitating urgent/inpatient dilation were more likely to be malignant than benign. Piotet et al. demonstrated similar findings in their analysis of 2387 strictures in which 55% of the cases requiring dilation were malignant and 45% were benign [3]. This finding is likely due to the rapid growth of malignant strictures and higher recurrence rate of symptoms necessitating repeated and urgent interventions.

The demographic characteristics of the subgroups showed that the malignant stricture group was slightly younger than the benign stricture group. This was likely a result of the high mortality of esophageal cancer, leading to a paucity of the older population and a lower mean age in this subgroup. Among male patients, there was a significant preponderance of malignant strictures requiring dilation. This is consistent with the higher prevalence of esophageal carcinoma in male patients reported in the literature [7].

Advances in endoscopic techniques and equipment have remarkably improved the safety of this procedure [8]. The in-hospital mortality for patients undergoing dilation was relatively low (1.4%). However, it was higher in the malignant stricture subgroup than in the benign stricture group. Similar trends in mortality were also reported by previous studies [3]. Our findings also demonstrated a longer length of stay among patients with malignant stricture. However, to mitigate the effect of delay in discharge due to placement in skilled nursing or rehabilitation facilities, an adjusted length of stay was calculated in which only those patients who were discharged alive and to a nonfacility location were considered. This adjusted length of stay was the same for the two groups, thus pointing out that the apparent difference between the two groups might be a result of the higher proportion of patients with malignant stricture being discharged to facilities than home.

Although infrequent, perforation is the most dreaded complication of endoscopic dilation for an endoscopist, owing to the high mortality rate associated with the procedure [5]. Previously published studies have shown perforation rates ranging from 0.1% to 5% [3,9-13]. These estimates were mostly from elective esophageal dilations; however, our findings suggest that the incidence of esophageal perforation is exceedingly low even with inpatient semi-urgent dilation procedures. This may partly be because of the better dilation techniques being utilized nowadays [14,15], further reiterating the notion that the overall risk of esophageal perforation remains relatively low in patients undergoing dilation of esophageal stricture. Although rare, perforation seems to be more commonly encountered with dilation of malignant strictures (0.9% vs. 0.5%). This trend is consistent with the existing literature on the subject [16,17]. It is likely a result of the increased friability associated with previous use of chemotherapy or radiation therapy. Overall, patients with malignant strictures had worse outcomes than those with benign strictures.

When esophageal dilation is unsuccessful in providing symptom relief, the next step in management is usually to seek alternative forms of nutrition. Palliative care with or without PEG/J placement is another reasonable option for patients with malignant stricture. Our findings show that 4.9% of patients who undergo inpatient esophageal dilation require placement of a PEG/J tube during that hospitalization, likely owing to an unsuccessful procedure or procedural complication. It was also seen that PEG/J was far more commonly utilized in patients with malignant stricture (14.1% vs. 4.5%), likely as a part of palliative care.

We also demonstrated that palliative care was utilized more often in patients with malignant stricture not undergoing dilation (6.6% vs. 3.1%). We conducted a multivariate logistic regression analysis to adjust for various patient-based and hospital-based confounders, such as the teaching status of the hospital, hospital location and region, bed size, weekend vs. weekday admission, age, race, sex, or other comorbidities. The odds of utilizing palliative care were twice as much if no dilation was performed. This may be because of the more advanced nature of cancer in this population. Palliative care in patients with esophageal cancer needs a multidisciplinary approach. Management of dysphagia involves endoscopic dilation and stenting; however, pain management is another crucial aspect, and palliative care physicians can be an essential part of the team in that regard. Although we found an increasing trend from 2007 to 2013 (Fig. 2), our study revealed the striking underutilization of palliative care services in this patient population [18].

Our study has some limitations. The proportion of patients presenting with acute food impaction or gradual failure to thrive among patients with malignant stricture is unclear. Moreover, information about the esophageal malignancy stage and treatment details such as prior chemo-radiation are not available, and these could have implications on the perforation rates. Furthermore, we could not account for patients undergoing repeat dilations.

In conclusion, dilation of esophageal strictures is commonly used in the hospital inpatient setting and is relatively safe. Although complications, particularly perforations, are rare, patients need to be carefully monitored and aggressively treated when perforations do occur. Patients with malignant esophageal strictures undergoing esophageal dilation have worse outcomes than patients with benign strictures.

Conflicts of Interest:The authors have no financial conflicts of interest.

Fig. 1.

Rate of esophageal perforation across different hospital characteristics.

Fig. 2.

Utilization of palliative care services among patients with malignant esophageal stricture.

Table 1.

Demographic Characteristics and Outcomes among Patients with Esophageal Stricture Undergoing Endoscopic Dilation

	Esophageal stricture	Malignant stricture subgroup	Benign stricture subgroup	p-value
Number of observations (% of total)	169,618 (100%)	7,896 (4.7%)	161,722 (95.3%)
Mean age in years (SD)	70.4 (15.4)	67.8 (11.5)	70.5 (15.5)	<0.001
Age categories (% of total), yr				<0.001
18–39	3.9	0.9	4.0
40–65	28.2	37.9	27.8
>65	67.9	61.2	68.2
Sex (% of total)				<0.001
Male	42.6	72.7	41.2
Female	57.4	27.3	58.8
Race (% of total)				0.01
Caucasian	71.0	68.6	71.2
African American	9.5	10.9	9.5
Others^a)	6.8	8.9	6.7
Missing	12.6	11.6	12.7
Grouped Charlson index (% of total)				<0.001
0	28.1	14.2	28.8
1	25.6	10.4	36.3
2	46.3	75.4	44.9
Outcomes
Median length of stay (IQR), d	4 (3–8)	5 (3–9)	4 (3–8)	0.01
Adjusted length of stay, d	4	4	4	N/A
Periprocedural mortality	1.5	3.1	1.4	<0.001
Esophageal perforation	0.5	0.9	0.5	0.007
PEG/J placement	4.9	14.1	4.5	<0.001

All the numbers reported in the table are in percentages unless otherwise specified.

SD, standard deviation; IQR, interquartile range; PEG/J, percutaneous endoscopic gastrostomy or jejunostomy; N/A, not available.

^a)Missing data for race have been reported separately in the table but was included with the “Others” category for the purpose of multivariate regression analysis.

Table 2.

Hospital Characteristics and Utilization of Palliative Care Services and PEG/J among Patients with Malignant Esophageal Stricture

	Dilation (n=7,896)	No dilation (n=16,789)	p-value
Hospital teaching status			<0.001
Teaching	38.3	45.8
Nonteaching	60.8	53.4
Missing	0.9	0.8
Hospital location			0.02
Rural	6.7	8.9
Urban	92.4	90.3
Missing	0.9	0.8
Hospital bed size			0.96
Small	9.8	10.2
Medium	22.3	21.8
Large	67.0	67.2
Missing	0.9	0.8
Hospital region			0.001
Northeast	25.6	21.9
Midwest	24.8	22.7
South	33.6	35.4
West	16.0	20.0
Utilization
PEG/J	14.1	20.5	<0.001
Palliative care services	3.1	6.6	<0.001

All numbers in the table are percentages unless otherwise specified.

PEG/J, percutaneous endoscopic gastrostomy or jejunostomy.

REFERENCES

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Figure & Data

REFERENCES

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Health-Care Utilization and Complications of Endoscopic Esophageal Dilation in a National Population

Clin Endosc. 2017;50(4):366-371. Published online March 17, 2017

DOI: https://doi.org/10.5946/ce.2016.155

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Health-Care Utilization and Complications of Endoscopic Esophageal Dilation in a National Population

Fig. 1. Rate of esophageal perforation across different hospital characteristics.

Fig. 2. Utilization of palliative care services among patients with malignant esophageal stricture.

Fig. 1.

Fig. 2.

Health-Care Utilization and Complications of Endoscopic Esophageal Dilation in a National Population

	Esophageal stricture	Malignant stricture subgroup	Benign stricture subgroup	p-value
Number of observations (% of total)	169,618 (100%)	7,896 (4.7%)	161,722 (95.3%)
Mean age in years (SD)	70.4 (15.4)	67.8 (11.5)	70.5 (15.5)	<0.001
Age categories (% of total), yr				<0.001
18–39	3.9	0.9	4.0
40–65	28.2	37.9	27.8
>65	67.9	61.2	68.2
Sex (% of total)				<0.001
Male	42.6	72.7	41.2
Female	57.4	27.3	58.8
Race (% of total)				0.01
Caucasian	71.0	68.6	71.2
African American	9.5	10.9	9.5
Others^a)	6.8	8.9	6.7
Missing	12.6	11.6	12.7
Grouped Charlson index (% of total)				<0.001
0	28.1	14.2	28.8
1	25.6	10.4	36.3
2	46.3	75.4	44.9
Outcomes
Median length of stay (IQR), d	4 (3–8)	5 (3–9)	4 (3–8)	0.01
Adjusted length of stay, d	4	4	4	N/A
Periprocedural mortality	1.5	3.1	1.4	<0.001
Esophageal perforation	0.5	0.9	0.5	0.007
PEG/J placement	4.9	14.1	4.5	<0.001

	Dilation (n=7,896)	No dilation (n=16,789)	p-value
Hospital teaching status			<0.001
Teaching	38.3	45.8
Nonteaching	60.8	53.4
Missing	0.9	0.8
Hospital location			0.02
Rural	6.7	8.9
Urban	92.4	90.3
Missing	0.9	0.8
Hospital bed size			0.96
Small	9.8	10.2
Medium	22.3	21.8
Large	67.0	67.2
Missing	0.9	0.8
Hospital region			0.001
Northeast	25.6	21.9
Midwest	24.8	22.7
South	33.6	35.4
West	16.0	20.0
Utilization
PEG/J	14.1	20.5	<0.001
Palliative care services	3.1	6.6	<0.001

Table 1. Demographic Characteristics and Outcomes among Patients with Esophageal Stricture Undergoing Endoscopic Dilation

All the numbers reported in the table are in percentages unless otherwise specified.

SD, standard deviation; IQR, interquartile range; PEG/J, percutaneous endoscopic gastrostomy or jejunostomy; N/A, not available.

Missing data for race have been reported separately in the table but was included with the “Others” category for the purpose of multivariate regression analysis.

Table 2. Hospital Characteristics and Utilization of Palliative Care Services and PEG/J among Patients with Malignant Esophageal Stricture

All numbers in the table are percentages unless otherwise specified.

PEG/J, percutaneous endoscopic gastrostomy or jejunostomy.