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Original Article
Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy
Jae Hyun Kim, Sanghwan Byun, Youn Jung Choi, Hye Jung Kwon, Kyoungwon Jung, Sung Eun Kim, Moo In Park, Won Moon, Seun Ja Park
Clin Endosc 2020;53(5):555-561.   Published online March 31, 2020
DOI: https://doi.org/10.5946/ce.2019.210
AbstractAbstract PDFPubReaderePub
Background
/Aims: In this study, we compared the efficacy and safety of etomidate with those of propofol or midazolam for the maintenance of sedation during endoscopy.
Methods
The study enrolled patients who underwent sedative endoscopy in our hospital and divided them into three groups. Patients in each group were administered midazolam as induction therapy and were subsequently administered either midazolam (M + M group), propofol (M + P group), or etomidate (M + E group) as maintenance medication. The primary outcome was overall cardiovascular and respiratory adverse events.
Results
In total, 105 patients who underwent sedative endoscopic examination were enrolled. The outcomes related to the procedure and sedation were not significantly different among the groups. Overall cardiovascular and respiratory adverse events were observed in 9 patients (25.7%) in the M + M group, 8 patients (23.5%) in the M + P group, and 10 patients (27.8%) in the M + E group. The logistic regression analysis revealed that etomidate use was not an independent risk factor for overall cardiovascular and respiratory adverse events.
Conclusions
The outcomes following the use of etomidate for maintenance after induction with midazolam for sedation in upper gastrointestinal endoscopy were not inferior to those following midazolam or propofol use from the perspectives of safety and efficacy.

Citations

Citations to this article as recorded by  
  • Comparison of ciprofol–alfentanil and propofol–alfentanil sedation during bidirectional endoscopy: A prospective, double-blind, randomised, controlled trial
    Jiqiang Zhang, Ruijuan Liu, Ruirui Bi, Xia Li, Mengjun Xu, Lijuan Li, Yuxi su, Wenjun Yan
    Digestive and Liver Disease.2024; 56(4): 663.     CrossRef
  • Effects of Earmuffs and Eye Masks on Propofol Sedation during Spinal Anesthesia for Orthopedic Surgery: A Randomized Controlled Trial
    Jin-Woo Park, Sung Il Bae, Jungyul Ryu, Seung Hyun Chung, Sang-Hwan Do
    Journal of Clinical Medicine.2023; 12(3): 899.     CrossRef
  • Effect of intravenous anesthesia by etomidate in combination with propofol on gastrointestinal endoscopy
    Bo CHEN, Ke ZHANG, Mingshuai YU
    Minerva Surgery.2023;[Epub]     CrossRef
  • New sedatives and analgesic drugs for gastrointestinal endoscopic procedures
    Jae Min Lee, Yehyun Park, Jin Myung Park, Hong Jun Park, Jun Yong Bae, Seung Young Seo, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Jun Kyu Lee, Byung-Wook Kim
    Clinical Endoscopy.2022; 55(5): 581.     CrossRef
  • Drugs used for sedation in gastrointestinal endoscopy
    Jun Kyu Lee
    Journal of the Korean Medical Association.2022; 65(11): 735.     CrossRef
  • Comparative Safety Profiles of Sedatives Commonly Used in Clinical Practice: A 10-Year Nationwide Pharmacovigilance Study in Korea
    Yeo-Jin Choi, Seung-Won Yang, Won-Gun Kwack, Jun-Kyu Lee, Tae-Hee Lee, Jae-Yong Jang, Eun-Kyoung Chung
    Pharmaceuticals.2021; 14(8): 783.     CrossRef
  • Physical and Chemical Compatibility of Etomidate and Propofol Injectable Emulsions
    Chunling Wang, Shengnan Wang, Cuishuan Wu, Li Lei, Dong-Xin Wang, Qiang Zhang
    Pharmacology.2021; 106(11-12): 644.     CrossRef
  • 4,881 View
  • 199 Download
  • 9 Web of Science
  • 7 Crossref
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Commentary
When Should We Perform Endoscopy for Patients with Upper Gastrointestinal Bleeding?
Kyoungwon Jung, Moo In Park
Clin Endosc 2019;52(1):1-2.   Published online January 17, 2019
DOI: https://doi.org/10.5946/ce.2019.007
PDFPubReaderePub
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Original Article
Effect of Sending Educational Video Clips via Smartphone Mobile Messenger on Bowel Preparation before Colonoscopy
Sung Chan Jeon, Jae Hyun Kim, Sun Jung Kim, Hye Jung Kwon, Youn Jung Choi, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
Clin Endosc 2019;52(1):53-58.   Published online August 29, 2018
DOI: https://doi.org/10.5946/ce.2018.072
AbstractAbstract PDFPubReaderePub
Background
/Aim: We aimed to evaluate the efficacy of sending educational video clips via smartphone mobile messenger (SMM) on enhancing bowel preparation before colonoscopy.
Methods
This was a prospective, endoscopist-blinded, randomized controlled study. Patients in the SMM group received two video clips sent via SMM that explained the diet and regimen for bowel preparation, whereas those in the control group did not receive any video clips. We compared the quality of bowel preparation between the two groups, which was assessed by an endoscopist using the Ottawa scale.
Results
Between August and November 2014, 140 patients in the SMM group and 141 patients in the control group underwent colonoscopic examination. The total Ottawa score of the SMM group was significantly lower than that of the control group (5.47±1.74 vs. 5.97±1.78, p=0.018). These results were particularly prominent in the younger age group; the total Ottawa score of patents in the SMM group aged <40 years was significantly lower than that of patients in the control group aged <40 years (5.10±1.55 vs. 6.22±2.33, p=0.034).
Conclusions
We demonstrated that sending educational video clips via SMM could result in better bowel preparation, especially in the younger age group.

Citations

Citations to this article as recorded by  
  • Evaluation of the effect of reinforced education on the satisfaction of patients undergoing colonoscopy: A randomized controlled trial
    Negin Farid, Shakila Sharifian, Raziyeh Ghafouri, Antonio Brillantino
    PLOS ONE.2024; 19(1): e0296126.     CrossRef
  • Can an educational video improve the adequacy of bowel preparation for patients undergoing their first colonoscopy? Results of the EBOPS RCT
    Thomas Archer, Bernard Corfe, Keith Dear, Andy Cole, Stephen Foley, H Jervoise N Andreyev, Waleed Fateen, Andrew Baxter, Stuart Riley, Adolfo Parra-Blanco, Mo Thoufeeq
    Endoscopy International Open.2024; 12(03): E402.     CrossRef
  • Improving Colonoscopy Preparation Using Information and Communication Technologies (ICT), Randomized Clinical Trial
    Diego Mauricio Aponte Martín, Claudia Liliana Corso Bernal, María Valentina Aponte Aparicio, Luis Carlos Sabbagh Sanvicente
    Revista colombiana de Gastroenterología.2024; 39(1): 51.     CrossRef
  • A smartphone application to enhance bowel preparation for first-time colonoscopy: a randomized controlled study
    Tanawat Pattarapuntakul, Thanyaporn Kanchanasuwan, Apichat Kaewdech, Thanawin Wong, Nisa Netinatsunton, Nalerdon Chalermsuksant, Pimsiri Sripongpun
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Edukacinio 3D virtualiosios realybės vaizdo metodo įtaka ruošiant žarnyną kolonoskopijai: pirmieji rezultatai
    Edvinas Kildušis, Gintautas Brimas
    Lietuvos chirurgija.2024; 23(2): 108.     CrossRef
  • Effectiveness of bowel preparation innovative technology instructions (BPITIs) on clinical outcomes among patients undergoing colonoscopy: a systematic review and meta-analysis
    Parichat Wonggom, Siwanon Rattanakanokchai, Orathai Suebkinorn
    Scientific Reports.2023;[Epub]     CrossRef
  • Impact of WeChat guidance on bowel preparation for colonoscopy: a quasi-experiment study
    Yifang Guan, Yanjun Song, Xiaona Li, Aijun Zhang, Ruyuan Li
    Scientific Reports.2023;[Epub]     CrossRef
  • Correlation between prescribing doctor attributes and intestinal cleanliness in colonoscopy: a study of 22522 patients
    Haibin Zhou, Hayat Khizar, Xiaofeng Zhang, Jianfeng Yang
    Annals of Medicine.2023;[Epub]     CrossRef
  • An Interactive Video Educational Tool Does Not Improve the Quality of Bowel Preparation for Colonoscopy: A Randomized Controlled Study
    Ted B. Walker, Tricia A. Hengehold, Kevin Garza, Benjamin D. Rogers, Dayna Early
    Digestive Diseases and Sciences.2022; 67(6): 2347.     CrossRef
  • Comparison of 2 L Polyethylene Glycol Plus Ascorbic Acid and 4 L Polyethylene Glycol in Elderly Patients Aged 60–79: A Prospective Randomized Study
    Sung Hoon Jung, Chul-Hyun Lim, Tae-Geun Gweon, Jinsu Kim, Jung Hwan Oh, Kyu-Tae Yoon, Jee Young An, Jeong‑Seon Ji, Hwang Choi
    Digestive Diseases and Sciences.2022; 67(10): 4841.     CrossRef
  • Patient education by smartphones for bowel preparation before colonoscopy
    Peng Li, Xueqian He, Xufang Yang, Jing Du, Weiquan Wu, Jiangfeng Tu
    Journal of Gastroenterology and Hepatology.2022; 37(7): 1349.     CrossRef
  • Los efectos de la educación perfeccionada, realizada por enfermeros en la calidad de la preparación intestinal para colonoscopia
    Gamze Arslanca, Mahmure Aygün
    Revista Latino-Americana de Enfermagem.2022;[Epub]     CrossRef
  • Effect of nurse-performed enhanced patient education on colonoscopy bowel preparation quality
    Gamze Arslanca, Mahmure Aygün
    Revista Latino-Americana de Enfermagem.2022;[Epub]     CrossRef
  • Os efeitos da educação aprimorada, realizada por enfermeiros na qualidade do preparo intestinal para colonoscopia
    Gamze Arslanca, Mahmure Aygün
    Revista Latino-Americana de Enfermagem.2022;[Epub]     CrossRef
  • Comparison of Two Types of 1-L Polyethylene Glycol-ascorbic Acid as Colonoscopic Bowel Preparation: A Prospective Randomized Study
    Suh Hyun Choi, Won Eui Yoon, Seung Hyuk Kim, Hee Jun Myung, Seo Hyun Kim, Soon Oh So, Se Hun Kim, Hyun Mi Lee, Yeoun Jung Oh, Jeong Seop Moon, Tae Yeong Park, You Sun Kim
    The Korean Journal of Gastroenterology.2022; 80(2): 85.     CrossRef
  • Multimedia based education on bowel preparation improves adenoma detection rate: Systematic review & meta‐analysis of randomized controlled trials
    Saurabh Chandan, Sumant Arora, Babu P. Mohan, Shahab R. Khan, Ojasvini C. Chandan, Lena L. Kassab, Arvind R. Murali
    Digestive Endoscopy.2021; 33(5): 730.     CrossRef
  • Mobile health technologies supporting colonoscopy preparation: A systematic review and meta-analysis of randomized controlled trials
    Maria El Bizri, Mariam El Sheikh, Ga Eun Lee, Maida J. Sewitch, Tim Mathes
    PLOS ONE.2021; 16(3): e0248679.     CrossRef
  • Effects of mobile messenger counseling on case management success for individuals engaging in self-harm or suicide attempts who were discharged from emergency departments
    Ji Min Seong, Youngsuk Cho, Gyu Chong Cho, Jongshill Lee, In Young Kim, Hongtaek Seo, Jungmi Kim
    Clinical and Experimental Emergency Medicine.2021; 8(1): 48.     CrossRef
  • Quality Improvement of Bowel Preparation for Screening Colonoscopies: A Study of Hospital Team Resource Management in Taiwan
    Chen-Shuan Chung, Chih-Ming Lin, Ming-Shu Chen
    Quality Management in Health Care.2021; 30(2): 127.     CrossRef
  • Effects of a Personalized Smartphone App on Bowel Preparation Quality: Randomized Controlled Trial
    Quirine E W van der Zander, Ankie Reumkens, Bas van de Valk, Bjorn Winkens, Ad A M Masclee, Rogier J J de Ridder
    JMIR mHealth and uHealth.2021; 9(8): e26703.     CrossRef
  • Safe and appropriate use of laxatives for colonoscopy
    Won Shik Kim, Beom Jae Lee
    Journal of the Korean Medical Association.2021; 64(8): 561.     CrossRef
  • Editors' Choice of Noteworthy Clinical Endoscopy Publications in the First Decade
    Gwang Ha Kim, Kwang An Kwon, Do Hyun Park, Jimin Han
    Clinical Endoscopy.2021; 54(5): 633.     CrossRef
  • Comparative Effectiveness of Enhanced Patient Instructions for Bowel Preparation Before Colonoscopy: Network Meta-analysis of 23 Randomized Controlled Trials
    Xu Tian, Li-Juan Yi, Yang Han, Hui Chen, Xiao-Ling Liu, Wei-Qing Chen, Maria F Jiménez-Herrera
    Journal of Medical Internet Research.2021; 23(10): e19915.     CrossRef
  • Influence of Educational Methods on Bowel Preparation for Coloncopy: Systematic Literature Review
    Edvinas Kildušis, Gintautas Brimas
    Lietuvos chirurgija.2021; 20(3-4): 135.     CrossRef
  • Educating Patients by Providing Timely Information Using Smartphone and Tablet Apps: Systematic Review
    Thomas Timmers, Loes Janssen, Rudolf B Kool, Jan AM Kremer
    Journal of Medical Internet Research.2020; 22(4): e17342.     CrossRef
  • How Can We Achieve Good Compliance for Bowel Preparation?
    Jongha Park, Tae Oh Kim
    Clinical Endoscopy.2019; 52(1): 3.     CrossRef
  • 6,212 View
  • 213 Download
  • 26 Web of Science
  • 26 Crossref
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Review
Borrmann Type 4 Advanced Gastric Cancer: Focus on the Development of Scirrhous Gastric Cancer
Kyoungwon Jung, Moo In Park, Sung Eun Kim, Seun Ja Park
Clin Endosc 2016;49(4):336-345.   Published online July 25, 2016
DOI: https://doi.org/10.5946/ce.2016.057
AbstractAbstract PDFPubReaderePub
Early diagnosis of Borrmann type 4 advanced gastric cancer (AGC) is very important for improving the prognosis of AGC patients. Because there is no definite mass in most cases of Borrmann type 4 AGC, its accurate diagnosis via endoscopy requires an understanding of its pathogenesis and developmental process. Moreover, many people confuse linitis plastica (LP) type gastric cancer (GC), scirrhous GC, and Borrmann type 4 AGC. To distinguish each of these cancers, knowledge of their endoscopic and pathological differences is necessary, especially for LP type GCs in the developmental stage. In conclusion, diagnosis of pre-stage or latent LP type GC before progression to typical LP type GC requires the detection of IIc-like lesions in the fundic gland area. It is also crucial to identify any abnormalities such as sclerosis of the gastric wall and hypertrophy of the mucosal folds during endoscopy.

Citations

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    International Journal of Biological Macromolecules.2024; 260: 129397.     CrossRef
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  • 17,419 View
  • 338 Download
  • 35 Web of Science
  • 30 Crossref
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Original Article
Observer Variability in Gastric Neoplasm Assessment Using the Vessel Plus Surface Classification for Magnifying Endoscopy with Narrow Band Imaging
Chan Hui Yoo, Moo In Park, Seun Ja Park, Won Moon, Hyung Hun Kim, Jun Young Song, Do Hyun Kim
Clin Endosc 2014;47(1):74-78.   Published online January 24, 2014
DOI: https://doi.org/10.5946/ce.2014.47.1.74
AbstractAbstract PDFPubReaderePub
Background/Aims

Recent studies have demonstrated that magnifying endoscopy with narrow band imaging (ME-NBI) facilitates differentiation of early gastric cancer from gastric adenoma using vessel plus surface (VS) classification. This study estimated the interobserver and intraobserver agreement of endoscopists using the Yao VS classification system for the gastric mucosal surface.

Methods

We retrospectively reviewed patients who underwent endoscopic submucosal dissection or endoscopic mucosal resection, and selected cases in which preoperative ME-NBI was conducted. Before testing endoscopists, a 20-minute training module was given. Static ME-NBI images (n=47 cases) were presented to seven endoscopists (two experts and five trainees) who were asked to assess the images in 20 seconds using the Yao VS classification system. After 2 weeks, the endoscopists were asked to analyze the images again. The κ statistic was calculated for intraobserver and interobserver variability.

Results

The mean κ for intraobserver agreement was 0.69 (experts, 0.74; trainees, 0.64). The mean κ for interobserver agreement was 0.42 (experts, 0.49; trainees, 0.40).

Conclusions

We obtained reliable results as assessed by observer variability, with only brief training on VS classification. The VS classification appears to provide an objective assessment of ME-NBI for trainees who are not familiar with ME-NBI.

Citations

Citations to this article as recorded by  
  • Performance of an artificial intelligence‐based diagnostic support tool for early gastric cancers: Retrospective study
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Case Report
Successful Endoscopic Mucosal Resection of a Low Esophageal Carcinoid Tumor
Chang Sup Lim, Seun Ja Park, Moo In Park, Won Moon, Hyung Hun Kim, Jun Sik Lee, Bong Jin Kim, Dong Young Ku
Clin Endosc 2013;46(5):576-578.   Published online September 30, 2013
DOI: https://doi.org/10.5946/ce.2013.46.5.576
AbstractAbstract PDFPubReaderePub

Esophageal carcinoid tumors remain some of the rarest of all carcinoid tumors, with only several cases previously reported in the literature. The endoscopic mucosal resection of selected carcinoid tumors has been shown to be a valid, safe, and effective method of treatment. Endoscopic ultrasonography is the technique of choice to select patients eligible for endoscopic resection. Here, we report successful endoscopic mucosal resection of a low esophageal carcinoid tumor and review the relevant literature. The present case is the first reported case of esophageal carcinoid tumor in Korea.

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Special Issue Article of IDEN 2013
Endoscopic Treatment for Early Foregut Neuroendocrine Tumors
Moo In Park
Clin Endosc 2013;46(5):450-455.   Published online September 30, 2013
DOI: https://doi.org/10.5946/ce.2013.46.5.450
AbstractAbstract PDFPubReaderePub

Foregut neuroendocrine tumors (NETs) include those arising in the esophagus, stomach, pancreas, and duodenum and seem to have a broad range of clinical behavior from benign to metastatic. Several factors including the advent of screening endoscopy may be related to increased incidence of gastrointestinal NETs; thus, many foregut NETs are diagnosed at an early stage. Early foregut NETs, such as those of the stomach and duodenum, can be managed with endoscopic treatment because of a low frequency of lymph node and distant metastases. However, controversy continues concerning the optimal management of early foregut NETs due to a lack of controlled prospective studies. Several issues such as indications, technical issues, and outcomes of endoscopic treatment for early foregut NETs are reviewed based on some published studies.

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Original Article
Effectiveness of Premedication with Pronase for Visualization of the Mucosa during Endoscopy: A Randomized, Controlled Trial
Gyu Jin Lee, Seun Ja Park, Sun Jung Kim, Hyung Hun Kim, Moo In Park, Won Moon
Clin Endosc 2012;45(2):161-164.   Published online June 30, 2012
DOI: https://doi.org/10.5946/ce.2012.45.2.161
AbstractAbstract PDFPubReaderePub
Background/Aims

Gastric mucus should be removed before endoscopic examination to increase visibility. In this study, the effectiveness of premedication with pronase for improving visibility during endoscopy was investigated.

Methods

From April 2010 to February 2011, 400 outpatients were randomly assigned to receive endoscopy with one of four premedications as follows: dimethylpolysiloxane (DMPS), pronase and sodium bicarbonate with 10 minutes premedication time (group A, n=100), DMPS and sodium bicarbonate with 10 minutes premedication time (group B, n=100), DMPS, pronase and sodium bicarbonate with 20 minutes premedication time (group C, n=100), and DMPS and sodium bicarbonate with 20 minute premedication time (group D, n=100). One endoscopist, who was unaware of the premedication types, calculated the visibility scores (range, 1 to 3) of the antrum, lower gastric body, upper gastric body and fundus. The sum of the scores from the four locations was defined as the total visibility score.

Results

Group C showed significantly lower scores than other groups (p=0.002). Group C also had the lowest frequency of flushing, which was significantly lower than that of group D. Groups C and D had significantly shorter durations of examination than groups A and B.

Conclusions

Using pronase 20 minutes before endoscopy significantly improved endoscopic visualization and decreased the frequency of water flushing.

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