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Volume 48(6); November 2015
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Commentarys
Can AIMS65 Save the Endoscopists from Midnight Calls?
Joon Sung Kim, Byung-Wook Kim
Clin Endosc 2015;48(6):459-460.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.459
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Narrow Band Imaging as an Efficient and Economical Tool in Diagnosing Colorectal Polyps
Naoki Muguruma, Tetsuji Takayama
Clin Endosc 2015;48(6):461-463.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.461
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Can Endoscopic Nasobiliary Drainage Involving Two Catheters Be Used to Treat Various Conditions?
Dong Wook Lee, Ho Gak Kim
Clin Endosc 2015;48(6):464-465.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.464
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Focused Review Series: Image Enhanced Endoscopys
The Past, Present, and Future of Image-Enhanced Endoscopy
Jae-Young Jang
Clin Endosc 2015;48(6):466-475.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.466
AbstractAbstract PDFPubReaderePub
Despite the remarkable progress recently made to enhance the resolution of white-light endoscopy, detection, and diagnosis of premalignant lesions, such as adenomas and subtle early-stage cancers, remains a great challenge. As for example, although chromoendoscopy, such as endoscopy using indigo carmine, is useful for the early diagnosis of subtle lesions, the technique presents various disadvantages ranging from the time required for spray application of the dye and suctioning of excess dye to the increased difficulty in identifying lesions in the presence of severe inflammation and obstruction of visual field due to the pooling of solution in depressed-type lesions. To overcome these diagnostic problems associated with chromoendoscopy, research has focused on the development of endoscopes based on new optical technologies. Several types of image-enhanced endoscopy methods have recently been presented. In particular, image-enhanced endoscopy has emerged as a new paradigm for the diagnosis of gastrointestinal disorders. Image-enhanced endoscopes provide high-contrast images of lesions by means of optical or electronic technologies, including the contrast enhancement of the mucosal surface and of blood vessels. Chromoendoscopy, narrow-band imaging, i-SCAN, and flexible spectral imaging color enhancement are representative examples of image-enhanced endoscopy discussed in this paper.

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Narrow Band Imaging: Technology Basis and Research and Development History
Kazuhiro Gono
Clin Endosc 2015;48(6):476-480.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.476
AbstractAbstract PDFPubReaderePub
The first launch of narrow band imaging (NBI) was in 2005. Since then, in most countries where gastrointestinal endoscopies are performed, NBI is the most commonly used optical digital method of performing image-enhanced endoscopy. Thanks to the outstanding efforts of many endoscopists, many clinical studies have been performed and clinical evidence has been gathered. In Japan, since 2010, NBI has been reimbursed under the Japanese national health insurance system. This is owing to the establishment of clinical evidence by physicians. However, even though endoscope systems with NBI function have been widely used outside of Japan, dissemination of knowledge on how to use NBI is insufficient. In this review paper, the technology basis of NBI and its research and development history are described. I hope this information will be helpful for updating physicians’ knowledge of NBI.

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Clinical Application of Magnifying Endoscopy with Narrow-Band Imaging in the Stomach
Kenshi Yao
Clin Endosc 2015;48(6):481-490.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.481
AbstractAbstract PDFPubReaderePub
Magnifying endoscopy with narrow-band imaging (M-NBI) can visualize superficial microanatomies in the stomach. The normal morphology of the microanatomy visualized by M-NBI differs according to the part of the stomach. The gastric fundic glandular mucosa appears as a regular honeycomb-like subepithelial capillary network (SECN) pattern with a regular collecting venule pattern and regular oval crypt opening with circular marginal crypt epithelium (MCE) pattern. The gastric pyloric glandular mucosa displays a regular coil-shaped SECN pattern and regular polygonal or curved MCE pattern. For a diagnosis of early gastric cancer using M-NBI, the vessel plus surface classification system was developed. This system is clinically useful for the differential diagnosis of focal gastritis and small depressed cancer and for determining the horizontal extent of early gastric cancer for successful endoscopic resection. Advantages of M-NBI over conventional endoscopic imaging techniques with white light include accurate diagnosis and cost effectiveness. This technique is a breakthrough in the endoscopic diagnostic field.

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Polyp Detection, Characterization, and Management Using Narrow-Band Imaging with/without Magnification
Takahiro Utsumi, Mineo Iwatate, Wataru Sano, Hironori Sunakawa, Santa Hattori, Noriaki Hasuike, Yasushi Sano
Clin Endosc 2015;48(6):491-497.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.491
AbstractAbstract PDFPubReaderePub
Narrow-band imaging (NBI) is a new imaging technology that was developed in 2006 and has since spread worldwide. Because of its convenience, NBI has been replacing the role of chromoendoscopy. Here we review the efficacy of NBI with/without magnification for detection, characterization, and management of colorectal polyps, and future perspectives for the technology, including education. Recent studies have shown that the next-generation NBI system can detect significantly more colonic polyps than white light imaging, suggesting that NBI may become the modality of choice from the beginning of screening. The capillary pattern revealed by NBI, and the NBI International Colorectal Endoscopic classification are helpful for prediction of histology and for estimating the depth of invasion of colorectal cancer. However, NBI with magnifying colonoscopy is not superior to magnifying chromoendoscopy for estimation of invasion depth. Currently, therefore, chromoendoscopy should also be performed additionally if deep submucosal invasive cancer is suspected. If endoscopists become able to accurately estimate colorectal polyp pathology using NBI, this will allow adenomatous polyps to be resected and discarded; thus, reducing both the risk of polypectomy and costs. In order to achieve this goal, a suitable system for education and training in in vivo diagnostics will be necessary.

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Advanced Imaging Technology in Biliary Tract Diseases:Narrow-Band Imaging of the Bile Duct
Hyun Jong Choi, Jong Ho Moon, Yun Nah Lee
Clin Endosc 2015;48(6):498-502.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.498
AbstractAbstract PDFPubReaderePub
Newly introduced direct peroral cholangioscopy and the development of video choledochoscopes have enabled more defined observation of bile duct mucosal lesions with clearer images. Narrow-band imaging (NBI) is a unique endoscopic imaging technology that provides enhanced endoscopic images of surface mucosal structures and its superficial microvessels. Advanced cholangioscopy and NBI are expected to be useful for precise evaluation and correct diagnosis of biliary tract diseases. However, the diagnostic value of advanced bile duct imaging with cholangioscopy requires further evaluation.

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Advanced Imaging Technology Other than Narrow Band Imaging
Jun-Hyung Cho
Clin Endosc 2015;48(6):503-510.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.503
AbstractAbstract PDFPubReaderePub
To improve the detection rate of gastrointestinal tumors, image-enhanced endoscopy has been widely used during screening and surveillance endoscopy in Korea. In addition to narrow band imaging (NBI) with/without magnification, various types of electronic chromoendoscopies have been used, including autofluorescence imaging, I-scan, and flexible spectral imaging color enhancement. These technologies enable the accurate characterization of tumors because they enable visualization of microvascular and microsurface patterns. The present review focuses on understanding the principle and clinical applications of advanced imaging technologies other than NBI.

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Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
Sang Kil Lee
Clin Endosc 2015;48(6):511-515.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.511
AbstractAbstract PDFPubReaderePub
Confocal laser endomicroscopy (CLE) is a new technology enabling endoscopists to visualize tissue at the cellular level. CLE has the fundamental potential to provide a histologic diagnosis, and may theoretically replace or reduce the need for performing biopsy for histology. The clinical benefits of CLE are more obvious in esophageal disease, including Barrett’s esophagus. Currently, this technology has been adapted to the diagnosis and surveillance of Barrett’s esophagus and related neoplasia. Standard white light endoscopy is the primary tool for gastric cancer screening. Currently, the only method available to precisely diagnose these lesions is upper endoscopy with an appropriate biopsy. A recent study showed that CLE could characterize dysplasia or cancer and identify the risk factors for gastric cancer, such as intestinal metaplasia and the presence of Helicobacter pylori in vivo, although fewer studies on CLE were performed on the stomach than on Barrett’s esophagus and other esophageal diseases. However, the application of CLE to routine clinical endoscopy continues to be refined. This review focused on the usefulness and future prospects of CLE for gastric premalignant and malignant lesions.

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  • Newly proposed quantitative criteria can assess chronic atrophic gastritis via probe-based confocal laser endomicroscopy (pCLE): a pilot study
    Carlos Robles-Medranda, Miguel Puga-Tejada, Roberto Oleas, Jorge Baquerizo-Burgos, Juan Alcívar-Vásquez, Raquel Del Valle, Carlos Cifuentes-Gordillo, Haydee Alvarado-Escobar, Daniel Ponce-Velez, Jesenia Ospina-Arboleda, Hannah Pitanga-Lukashok
    Endoscopy International Open.2022; 10(04): E297.     CrossRef
  • Probe-Based Confocal Laser Endomicroscopy versus White-Light Endoscopy with Narrow-Band Imaging for Predicting and Collecting Residual Cancer Tissue in Patients with Gastric Cancer Receiving Chemotherapy
    Yuna Kim, Hyunki Kim, Minkyu Jung, Sun Young Rha, Hyun Cheol Chung, Sang Kil Lee
    Cancers.2022; 14(17): 4319.     CrossRef
  • Usefulness of Probe-Based Confocal Laser Endomicroscopy for Esophageal Squamous Cell Neoplasm
    Sang Kil Lee
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    Violet Kayamba, Aaron Shibemba, Kanekwa Zyambo, Douglas C. Heimburger, Douglas R. Morgan, Paul Kelly, Esaki M. Shankar
    PLOS ONE.2017; 12(9): e0184272.     CrossRef
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Original Articles
An Ultrathin Endoscope with a 2.4-mm Working Channel Shortens the Esophagogastroduodenoscopy Time by Shortening the Suction Time
Satoshi Shinozaki, Yoshimasa Miura, Yuji Ino, Kenjiro Shinozaki, Alan Kawarai Lefor, Hironori Yamamoto
Clin Endosc 2015;48(6):516-521.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.516
Correction in: Clin Endosc 2016;49(1):100
AbstractAbstract PDFPubReaderePub
Background
/Aims: Poor suction ability through a narrow working channel prolongs esophagogastroduodenoscopy (EGD). The aim of this study was to evaluate suction with a new ultrathin endoscope (EG-580NW2; Fujifilm Corp.) having a 2.4-mm working channel in clinical practice.
Methods
To evaluate in vitro suction, 200 mL water was suctioned and the suction time was measured. The clinical data of 117 patients who underwent EGD were retrospectively reviewed on the basis of recorded video, and the suction time was measured by using a stopwatch.
Results
In vitro, the suction time with the EG-580NW2 endoscope was significantly shorter than that with the use of an ultrathin endoscope with a 2.0-mm working channel (EG-580NW; mean ± standard deviation, 22.7±1.1 seconds vs. 34.7±2.2 seconds; p<0.001). We analyzed the total time and the suction time for routine EGD in 117 patients (50 in the EG-580NW2 group and 67 in the EG-580NW group). In the EG-580NW2 group, the total time for EGD was significantly shorter than that in the EG-580NW group (275.3±42.0 seconds vs. 300.6±46.5 seconds, p=0.003). In the EG-580NW2 group, the suction time was significantly shorter than that in the EG-580NW group (19.2±7.6 seconds vs. 38.0±15.9 seconds, p<0.001).
Conclusions
An ultrathin endoscope with a 2.4-mm working channel considerably shortens the routine EGD time by shortening the suction time, in comparison with an endoscope with a 2.0-mm working channel.

Citations

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  • Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives
    Jang Ah Kim, Dominic J Wales, Guang-Zhong Yang
    Progress in Biomedical Engineering.2020; 2(4): 042001.     CrossRef
  • Necessity of transnasal gastroscopy in routine diagnostics: a patient-centred requirement analysis
    Anna-Livia Schuldt, Holger Kirsten, Jan Tuennemann, Mario Heindl, Florian van Bommel, Juergen Feisthammel, Marcus Hollenbach, Albrecht Hoffmeister
    BMJ Open Gastroenterology.2019; 6(1): e000264.     CrossRef
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The AIMS65 Score Is a Useful Predictor of Mortality in Patients with Nonvariceal Upper Gastrointestinal Bleeding: Urgent Endoscopy in Patients with High AIMS65 Scores
Sun Wook Park, Young Wook Song, Dae Hyun Tak, Byung Moo Ahn, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong
Clin Endosc 2015;48(6):522-527.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.522
AbstractAbstract PDFPubReaderePub
Background
/Aims: To validate the AIMS65 score for predicting mortality of patients with nonvariceal upper gastrointestinal bleeding and to evaluate the effectiveness of urgent (<8 hours) endoscopic procedures in patients with high AIMS65 scores.
Methods
This was a 5-year single-center, retrospective study. Nonvariceal, upper gastrointestinal bleeding was assessed by using the AIM65 and Rockall scores. Scores for mortality were assessed by calculating the area under the receiver-operating characteristic curve (AUROC). Patients with high AIMS65 scores (≥2) were allocated to either the urgent or non-urgent endoscopic procedure group. In-hospital mortality, success of endoscopic procedure, recurrence of bleeding, admission period, and dose of transfusion were compared between groups.
Results
A total of 634 patients were analyzed. The AIMS65 score successfully predicted mortality (AUROC=0.943; 95% confidence interval [CI], 0.876 to 0.99) and was superior to the Rockall score (AUROC=0.856; 95% CI, 0.743 to 0.969) in predicting mortality. The group with high AIMS65 score included 200 patients. The urgent endoscopic procedure group had reduced hospitalization periods (p<0.05)
Conclusions
AIMS65 score may be useful in predicting mortality in patients with nonvariceal upper gastrointestinal bleeding. Urgent endoscopic procedures in patients with high scores may be related to reduced hospitalization periods.

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  • ASSESSMENT OF PATIENTS WITH NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING USING AIMS65 SCORE
    Farahnaz Joukar, Raheleh Sadat Hosseini Basti, Fakhrieh Sadat Hosseini Basti, Fatemeh Mosafer, Hoorieh Sadat Hosseini Basti, Zahra Hedayatzadeh, Afshin Shafaghi
    Studies in Medical Sciences.2024; 35(1): 51.     CrossRef
  • Performance of Six Clinical Physiological Scoring Systems in Predicting In-Hospital Mortality in Elderly and Very Elderly Patients with Acute Upper Gastrointestinal Bleeding in Emergency Department
    Po-Han Wu, Shang-Kai Hung, Chien-An Ko, Chia-Peng Chang, Cheng-Ting Hsiao, Jui-Yuan Chung, Hao-Wei Kou, Wan-Hsuan Chen, Chiao-Hsuan Hsieh, Kai-Hsiang Ku, Kai-Hsiang Wu
    Medicina.2023; 59(3): 556.     CrossRef
  • Outcomes in Patients Admitted for Upper Gastrointestinal Bleeding and COVID-19 Infection: A Study of Two Years of the Pandemic
    Sergiu Cazacu, Daniela Burtea, Vlad Iovănescu, Dan Florescu, Sevastița Iordache, Adina Turcu-Stiolica, Victor Sacerdotianu, Bogdan Ungureanu
    Life.2023; 13(4): 890.     CrossRef
  • Pre-Endoscopic Scores Predicting Low-Risk Patients with Upper Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis
    Antoine Boustany, Ali A. Alali, Majid Almadi, Myriam Martel, Alan N. Barkun
    Journal of Clinical Medicine.2023; 12(16): 5194.     CrossRef
  • A nomogram to predict in-hospital mortality of gastrointestinal bleeding patients in the intensive care unit
    Xueyan Zhang, Jianfang Ni, Hongwei Zhang, Mengyuan Diao
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Scoring systems for predicting clinical outcomes in peptic ulcer bleeding
    Jin Hee Noh, Boram Cha, Ji Yong Ahn, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
    Medicine.2022; 101(36): e30410.     CrossRef
  • ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study
    Stig Borbjerg Laursen, Kathryn Oakland, Loren Laine, Vered Bieber, Riccardo Marmo, Eduardo Redondo-Cerezo, Harry R Dalton, Jeffrey Ngu, Michael Schultz, Marco Soncini, Ian Gralnek, Vipul Jairath, Iain A Murray, Adrian J Stanley
    Gut.2021; 70(4): 707.     CrossRef
  • AIMS65 scoring system is comparable to Glasgow-Blatchford score or Rockall score for prediction of clinical outcomes for non-variceal upper gastrointestinal bleeding
    Min Seong Kim, Jeongmin Choi, Won Chang Shin
    BMC Gastroenterology.2019;[Epub]     CrossRef
  • Comparison of three risk scores to predict outcomes in upper gastrointestinal bleeding; modifying Glasgow-Blatchford with albumin
    Afshin Shafaghi, Faeze Gharibpoor, Zahra Mahdipour, Ali Akbar Samadani
    Romanian Journal of Internal Medicine.2019; 57(4): 322.     CrossRef
  • Comparison of AIMS65, Glasgow–Blatchford and Rockall scoring approaches in predicting the risk of in-hospital death among emergency hospitalized patients with upper gastrointestinal bleeding: a retrospective observational study in Nanjing, China
    Lei Gu, Fei Xu, Jie Yuan
    BMC Gastroenterology.2018;[Epub]     CrossRef
  • How to Use Scoring Systems for Upper Gastrointestinal Bleeding?
    Heung Up Kim
    The Korean Journal of Gastroenterology.2016; 67(1): 1.     CrossRef
  • Risk Strategy in Non-Variceal Upper Gastrointestinal Bleeding
    Joon Sung Kim, Byung-Wook Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2016; 16(4): 173.     CrossRef
  • Comparison of three scoring systems in predicting clinical outcomes in patients with acute upper gastrointestinal bleeding: a prospective observational study
    Min Zhong, Wan Jun Chen, Xiao Ye Lu, Jie Qian, Chang Qing Zhu
    Journal of Digestive Diseases.2016; 17(12): 820.     CrossRef
  • Can AIMS65 Save the Endoscopists from Midnight Calls?
    Joon Sung Kim, Byung-Wook Kim
    Clinical Endoscopy.2015; 48(6): 459.     CrossRef
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A Randomized Controlled Clinical Study Comparing the Diagnostic Accuracy of the Histologic Prediction for Colorectal Polyps Depending on the Use of Either Magnified or Nonmagnified Narrow Band Imaging
Jin Joo Kim, Kyoung Sup Hong, Joo Sung Kim, Hyun Chae Jung
Clin Endosc 2015;48(6):528-533.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.528
AbstractAbstract PDFPubReaderePub
Background
/Aims: The aim of this study was to compare the diagnostic capabilities of narrow band imaging (NBI) colonoscopy with and without optical magnification in differentiating neoplastic from nonneoplastic colorectal polyps.
Methods
Between April 2012 and March 2013, 122 patients with colorectal polyps detected by using diagnostic conventional colonoscopy were prospectively enrolled. A total of 236 polyps were evaluated with NBI, in vivo in real time during therapeutic colonoscopy, by one experienced endoscopist. Whether magnification was used or not was determined by randomization. After an in vivo real-time endoscopic prediction of histology, all lesions were endoscopically excised. Surgical pathologic reports were used as the criterion standards. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of identifying neoplastic polyps were calculated.
Results
A total of 236 lesions with an average size of 5.6 mm in 122 patients were assessed (159 neoplastic, 77 nonneoplastic). The Sn, Sp, PPV, and NPV in differentiating neoplastic from nonneoplastic lesions with the magnified NBI were 97.5%, 83.3%, 94.0%, and 92.6%, respectively, whereas those of the nonmagnified NBI group were 97.5%, 85.1%, 91.7%, and 95.2%, respectively.
Conclusions
Nonmagnified NBI colonoscopy distinguishes neoplastic from nonneoplastic colorectal polyps as accurately as does magnified NBI colonoscopy.

Citations

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  • Utility of the narrow-band imaging international colorectal endoscopic classification for optical diagnosis of colorectal polyp histology in clinical practice: a retrospective study
    Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Reiko Yamada, Tomomi Yamada, Yoshiyuki Takei
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Feasibility of using narrow band imaging international colorectal endoscopic classification for diagnosing colorectal neoplasia in China: A multicenter pilot observational study
    Qing Wei Zhang, Jing Jing Zhang, Ai Ming Yang, Jian Qiu Sheng, Yu Lan Liu, Zhao Shen Li, Hai Ying Chen, Nan Feng, Qing Wei Jiang, Peng Jin, Li Ming Zhang, Hong Yu Fu, Yun Jie Gao, Zhi Zheng Ge, Xiao Bo Li
    Journal of Digestive Diseases.2020; 21(2): 88.     CrossRef
  • Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy
    Sandra Barbeiro, Diogo Libânio, Rui Castro, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
    GE - Portuguese Journal of Gastroenterology.2019; 26(1): 40.     CrossRef
  • The value of narrow band imaging in diagnosis of head and neck cancer: a meta-analysis
    Hui Zhou, Jing Zhang, Linghong Guo, Ji Nie, Chenjing Zhu, Xuelei Ma
    Scientific Reports.2018;[Epub]     CrossRef
  • Comparison of narrow-band imaging and confocal laser endomicroscopy for the detection of neoplasia in Barrett's esophagus: A meta-analysis
    Yi-Quan Xiong, Shu-Juan Ma, Hao-Yue Hu, Jing Ge, Li-Zhi Zhou, Shu-Ting Huo, Min Qiu, Qing Chen
    Clinics and Research in Hepatology and Gastroenterology.2018; 42(1): 31.     CrossRef
  • Endoscopic classification for colorectal tumors using narrow‐band imaging
    Gian Eugenio Tontini, Helmut Neumann
    Digestive Endoscopy.2016; 28(5): 537.     CrossRef
  • Narrow Band Imaging as an Efficient and Economical Tool in Diagnosing Colorectal Polyps
    Naoki Muguruma, Tetsuji Takayama
    Clinical Endoscopy.2015; 48(6): 461.     CrossRef
  • 7,565 View
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Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an In Vivo Canine Model
Joung-Ho Han, Myounghwan Kim, Tae Hoon Lee, Hyun Kim, Yunho Jung, Seon Mee Park, Heebok Chae, Seijin Youn, Ji Yun Shin, In-Kwang Lee, Tae Soo Lee, Seok Hwa Choi
Clin Endosc 2015;48(6):534-541.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.534
AbstractAbstract PDFPubReaderePub
Background
/Aims: Endoscopic band ligation (EBL) is an accepted method in the management of variceal bleeding; however, there is little evidence on the safety and feasibility of EBL for the closure of bowel perforation. In this study, we aimed to evaluate the technical feasibility and efficacy of EBL in iatrogenic colon perforation by using a canine model.
Methods
We established an iatrogenic colon perforation model by using seven beagle dogs. Longitudinal 1.5- to 1.7-cm colon perforations were created with a needle knife and an insulated-tip knife, and the perforation was subsequently closed with EBL. During a 2-week follow-up period, the animals were carefully monitored and then euthanized for pathologic examination.
Results
The EBL of iatrogenic colon perforations was successful in all dogs. The mean procedure time for EBL closure with one to three bands was 191.7 seconds, and there were no immediate complications. One animal was euthanized after 3 days because of peritonitis. There were no clinical and laboratory features of sepsis or peritonitis in the remaining six animals. On necropsy, we did not find any fecal peritonitis, pericolonic abscess formation, or transmural dehiscence at the perforation site. Histopathology demonstrated inflamed granulation tissue and scar lesions replaced by fibrosis.
Conclusions
EBL might be a feasible and safe method for the management of iatrogenic colon perforations in an in vivo model.

Citations

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  • Endoscopic Management of Iatrogenic Colon Perforation
    Yunho Jung
    Clinical Endoscopy.2020; 53(1): 29.     CrossRef
  • Endoluminal closure of an unrecognized penetrating stab wound of the duodenum with endoscopic band ligation: A case report
    Dae Hoon Kim, Hanlim Choi, Ki Bae Kim, Hyo Yung Yun, Joung-Ho Han
    World Journal of Clinical Cases.2019; 7(20): 3271.     CrossRef
  • Endoscopic management of iatrogenic gastrointestinal perforations
    Kan Wang, Jihao Shi, Linna Ye
    Laparoscopic, Endoscopic and Robotic Surgery.2019; 2(2): 41.     CrossRef
  • Endoscopic Band Ligation Is Able to Close Perforations Caused by Colonoscopy: A Porcine Model Study
    Yidong Yang, Xianyi Lin, Siwei Tan, Xiaoli Huang, Zijun Xie, Xuan Xu, Yiming Lei, Bin Wu
    Gastroenterology Research and Practice.2018; 2018: 1.     CrossRef
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The Clinical Usefulness of Simultaneous Placement of Double Endoscopic Nasobiliary Biliary Drainage
Hong Jun Kim, Sung Koo Lee, Choong Heon Ryu, Do Hyun Park, Sang Soo Lee, Dong Wan Seo, Myung-Hwan Kim
Clin Endosc 2015;48(6):542-548.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.542
AbstractAbstract PDFPubReaderePub
Background
/Aims: To evaluate the technical feasibility and clinical efficacy of double endoscopic nasobiliary drainage (ENBD) as a new method of draining multiple bile duct obstructions.
Methods
A total of 38 patients who underwent double ENBD between January 2004 and February 2010 at the Asan Medical Center were retrospectively analyzed. We evaluated indications, laboratory results, and the clinical course.
Results
Of the 38 patients who underwent double ENBD, 20 (52.6%) had Klatskin tumors, 12 (31.6%) had hepatocellular carcinoma, 3 (7.9%) had strictures at the anastomotic site following liver transplantation, and 3 (7.9%) had acute cholecystitis combined with cholangitis. Double ENBD was performed to relieve multiple biliary obstruction in 21 patients (55.1%), drain contrast agent filled during endoscopic retrograde cholangiopancreatography in 4 (10.5%), obtain cholangiography in 4 (10.5%), drain hemobilia in 3 (7.9%), relieve Mirizzi syndrome with cholangitis in 3 (7.9%), and relieve jaundice in 3 (7.9%).
Conclusions
Double ENBD may be useful in patients with multiple biliary obstructions.

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  • High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide
    Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang
    Frontiers of Medicine.2020; 14(5): 651.     CrossRef
  • Can Endoscopic Nasobiliary Drainage Involving Two Catheters Be Used to Treat Various Conditions?
    Dong Wook Lee, Ho Gak Kim
    Clinical Endoscopy.2015; 48(6): 464.     CrossRef
  • 13,053 View
  • 95 Download
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Case Reports
Esophageal Lymphoepithelioma-Like Carcinoma with Unique Daisy-Like Appearance
Sehmus Olmez, Alper Can, Alpaslan Yavuz, Umit Haluk İliklerden, Gulay Bulut
Clin Endosc 2015;48(6):549-552.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.549
AbstractAbstract PDFPubReaderePub
Due to differences in prognosis and management, it is important to subclassify esophageal carcinoma. Esophageal lymphoepithelioma-like carcinoma (LELC) is extremely rare, with only a few cases reported to date. Review of the literature revealed case reports describing lesions with similar histology. We present a 69-year-old man with a giant pedunculated-polypoid lesion of the esophagus shrinking the lumen. Endoscopic excision of the tumor was performed and final histopathological diagnosis was confirmed to be LELC. In contrast to a previous case with a more aggressive course and a recurrent lesion, our patient died of his disease within 8 months of diagnosis. Here we discuss the endoscopic and radiologic findings of the case and a review of the literature.

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  • Analysis of genetic profiling, pathomics signature, and prognostic features of primary lymphoepithelioma‐like carcinoma of the renal pelvis
    Bo Fan, Yuanbin Huang, Hongshuo Zhang, Tingyu Chen, Shenghua Tao, Xiaogang Wang, Shuang Wen, Honglong Wang, Zhe Lin, Tianqing Liu, Hongxian Zhang, Tao He, Xiancheng Li
    Molecular Oncology.2022; 16(20): 3666.     CrossRef
  • Primary lymphoepithelioma-like carcinoma of the esophagus with metastatic lymph node and gastric cancer
    Kosuke Narumiya, Yosuke Yagawa, Kenji Kudo, Shinsuke Maeda, Yukinori Toyoshima, Kyohei Ogawa, Sho Izumika, Kimito Harada, Masayuki Itabashi, Harushi Osugi
    Clinical Journal of Gastroenterology.2021; 14(5): 1329.     CrossRef
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Endoscopic Submucosal Dissection for Recurrent or Residual Superficial Esophageal Cancer after Chemoradiotherapy: Two Cases
Changhyeok Hwang, Young Hoon Youn, Sung-eun Choi, Young Hak Jung, Hae Yeul Park, Jae Jun Park, Jie Hyun Kim, Hyojin Park
Clin Endosc 2015;48(6):553-557.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.553
AbstractAbstract PDFPubReaderePub
We report two cases of endoscopic submucosal dissection (ESD) for recurrent or residual esophageal squamous cell carcinoma (ESCC) lesions after chemoradiotherapy for advanced esophageal cancer. Case 1 involved a 64-year-old man who had previously undergone chemoradiotherapy for advanced ESCC and achieved a complete response (CR) for 22 months, until metachronous recurrent superficial ESCC was detected on follow-up esophagogastroduodenoscopy (EGD). We performed ESD and found no evidence of recurrence for 24 months. Case 2 involved a 59-year-old man who had previously undergone chemoradiotherapy for advanced ESCC. He responded favorably to treatment, and most of the tumor had disappeared on follow-up EGD 4 months later. However, there were two residual superficial esophageal lugol-voiding lesions. We performed ESD, and he had a CR for 32 months thereafter. ESD can be considered a viable treatment option for recurrent or residual superficial ESCC after chemoradiotherapy for advanced esophageal cancer.

Citations

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  • Clinical efficacy of endoscopic submucosal dissection in the treatment of early esophageal cancer and precancerous lesions
    Yue Wu, Haihui Zhang, Bingxi Zhou, Shuangyin Han, Yanrui Zhang
    Journal of Cancer Research and Therapeutics.2018; 14(1): 52.     CrossRef
  • 7,911 View
  • 56 Download
  • 2 Web of Science
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Eosinophilic Gastritis Presenting as Tissue Necrosis
Yong Min Jo, Jin Seok Jang, Seung Hee Han, Sang Hyun Kang, Woo Jae Kim, Jin Sook Jeong
Clin Endosc 2015;48(6):558-562.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.558
AbstractAbstract PDFPubReaderePub
Eosinophilic gastroenteritis is very rare disorder that is characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of any definite causes of eosinophilia. It is associated with various clinical gastrointestinal manifestations, and depends on the involved layer and site. We report a case of eosinophilic gastritis presenting with severe necrosis. The symptoms disappeared immediately after beginning steroid treatment, and the eosinophil count decreased to the reference range. The patient showed eosinophilic gastritis characterized by necrotic change such as necrotizing gastritis. It is a unique presentation of eosinophilic gastritis. To the best of our knowledge, no case of eosinophilic gastritis characterized by necrotic change such as necrotizing gastritis has been previously reported in Korea.
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Utility of Over-the-Scope Clipping for Closure of a Persistent Post-Percutaneous Endoscopic Gastrostomy Fistula under Long-Term Steroid Therapy
Yoshihisa Arao, Yuichi Sato, Satoru Hashimoto, Hiroki Honda, Kazumi Yoko, Masaaki Takamura, Ken-ichi Mizuno, Masaaki Kobayashi
Clin Endosc 2015;48(6):563-565.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.563
AbstractAbstract PDFPubReaderePub
A 50-year-old woman had a percutaneous endoscopic gastrostomy (PEG) tube placed after surgery for pharyngeal cancer. After 21 months, the PEG tube was removed due to improvement of per-oral ingestion. She had taken prednisolone for 31 years for systemic lupus erythematosus. The post-PEG fistula did not close spontaneously. The cause of the fistula was slow wound healing and gastrostomy site inflammation due to long-term steroid therapy. We were able to close the fistula with an over-the-scope clipping (OTSC) system. This case suggests that OTSC is useful for closing persistent post-PEG fistulas in patients receiving long-term prednisolone therapy.

Citations

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  • UEG Week 2016 Poster Presentations

    United European Gastroenterology Journal.2016; 4(5_suppl): A157.     CrossRef
  • 9,717 View
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Delayed Pneumoperitoneum and Acute Pulmonary Edema Secondary to Acute Gastric Dilatation
Jae Yun Ahn, Jong Kun Kim
Clin Endosc 2015;48(6):566-569.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.566
AbstractAbstract PDFPubReaderePub
Pneumoperitoneum caused by acute gastric dilatation (AGD) is a very rare complication. We report a case of pneumoperitoneum and acute pulmonary edema caused by AGD in a patient with Parkinson’s disease. A 78-year-old woman presented with pneumonia and AGD. We inserted a nasogastric tube and administered empirical antibiotics. We performed an endoscopy, and perforation or necrosis of the stomach and pyloric stenosis were not observed. Thirty-six hours after admission, the patient suddenly developed dyspnea and shock, and eventually died. We suspected the cause of death was pneumoperitoneum and acute pulmonary edema caused by AGD during the conservative treatment period. Immunocompromised patients with chronic illness require close observation even if they do not show any symptoms suggestive of complications. Even if the initial endoscopic or abdominal radiologic findings do not show gastric necrosis or perforation, follow-up with endoscopy is essential to recognize complications of AGD early.

Citations

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  • Acute gastric dilatation is a potentially fatal complication in Parkinson's disease
    Jiro Fukae, Masayoshi Kano, Asuka Nakajima, Atsuhito Fuse, Hiroto Eguchi, Karin Ashisawa, Masashi Takanashi, Nobutaka Hattori, Yasushi Shimo
    Parkinsonism & Related Disorders.2021; 85: 69.     CrossRef
  • 8,665 View
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Unexpected Delayed Colon Perforation after the Endoscopic Submucosal Dissection with Snaring of a Laterally Spreading Tumor
Young Bo Ko, Jeong-Mi Lee, Wan Soo Kim, Min Seob Kwak, Ji Wan Lee, Dong Yeol Shin, Dong-Hoon Yang, Jeong-Sik Byeon
Clin Endosc 2015;48(6):570-575.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.570
AbstractAbstract PDFPubReaderePub
Colonic perforation may occur as a complication of diagnostic and therapeutic colonoscopy. The risk factors for perforation after colorectal endoscopic submucosal dissection (ESD) include an inexperienced endoscopist, a large tumor size, and submucosal fibrosis. The mechanisms of perforation include unintended endoscopic resection/dissection and severe thermal injury. Here, we report a case of colon perforation that occurred after ESD with snaring of a laterally spreading tumor. The perforation was completely unexpected because there were no colorectal ESD-associated risk factors for perforation, deep dissection, or severe coagulation injury in our patient.

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  • Tri-Axial Force Sensor in a Soft Catheter Using Fiber Bragg Gratings for Endoscopic Submucosal Dissection
    Ramzi Ben Hassen, Arnaud Lemmers, Alain Delchambre
    IEEE Sensors Journal.2023; 23(20): 24626.     CrossRef
  • Factors for conversion risk of colorectal endoscopic submucosal dissection: a multicenter study
    Yuki Kamigaichi, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Akira Furudoi, Seiji Onogawa, Hideharu Okanobu, Takeshi Mizumoto, Tomohiro Miwata, Shiro Okamoto, Kenichi Yoshimura, Kazuaki Chayama
    Surgical Endoscopy.2022; 36(8): 5698.     CrossRef
  • Life on a knife edge: the optimal approach to the management of perforations during endoscopic submucosal dissection (ESD)
    Shria Kumar, Young Hoon Youn, Jeffrey H. Lee
    Expert Review of Gastroenterology & Hepatology.2020; 14(10): 965.     CrossRef
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    Ge-Yu-Jia Zhou, Jin-Long Hu, Sheng Wang, Nan Ge, Xiang Liu, Guo-Xin Wang, Si-Yu Sun, Jin-Tao Guo
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Successful Palliation of a Malignant Cologastric Fistula with a Covered Self-Expanding Metal Stent
Mathilde Therese Winther Breitenbauch, Anders Tøttrup
Clin Endosc 2015;48(6):576-578.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.576
AbstractAbstract PDFPubReaderePub
When patients present with malignant cologastric fistulas, the tumor stage is often advanced and management is only palliative. We report the case of a 75-year-old man with a symptomatic cologastric fistula arising from an advanced tumor in the transverse colon, previously stented owing to malignant obstruction. An 8-cm-long covered self-expanding metal stent (COMVI enteral colonic stent; Taewoong Medical) was placed inside the primary stent, which sealed the fistula and completely alleviated the symptoms. Considering the successful outcome, we propose that insertion of a covered stent be considered in the palliative management of patients with malignant cologastric fistulas.
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Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis
Ji Su Ha, Hyun Jong Choi, Jong Ho Moon, Yun Nah Lee, Jae Woong Tae, Moon Han Choi, Tae Hoon Lee, Sang-Woo Cha
Clin Endosc 2015;48(6):579-582.   Published online November 30, 2015
DOI: https://doi.org/10.5946/ce.2015.48.6.579
AbstractAbstract PDFPubReaderePub
Fasciola hepatica infection may result in biliary obstruction with or without cholangitis in the chronic biliary phase. Because clinical symptoms and signs of F. hepatica are similar to other biliary diseases that cause bile duct obstruction, such as stones or bile duct malignancies, that are, in fact, more common, this condition may not be suspected and diagnosis may be overlooked and delayed. Patients undergoing endoscopic retrograde cholangiopancreatography or endoscopic ultrasonography for the evaluation of bile duct obstruction may be incidentally detected with the worm, and diagnosis can be confirmed by extraction of the leaf-like trematode from the bile duct. Intraductal ultrasonography (IDUS) can provide high-resolution cross-sectional images of the bile duct, and is useful in evaluating indeterminate biliary diseases. We present a case of biliary fascioliasis that was diagnosed using IDUS and managed endoscopically in a patient with acute cholangitis.

Citations

Citations to this article as recorded by  
  • An Update on the Pathogenesis of Fascioliasis: What Do We Know?
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  • Fasciola Hepatica Induced Hepatic Abscess Treated with Triclabendazole
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    The Korean Journal of Gastroenterology.2021; 77(1): 39.     CrossRef
  • Biliary Fascioliasis in Chronic Calcific Pancreatitis Presenting with Ascending Cholangitis and Biliary Stricture
    Tanawat Pattarapuntakul, Bancha Ovartlarnporn, Worapot Rojsanga, Thanaidpon Yungyoo
    Case Reports in Gastroenterology.2019; 13(3): 438.     CrossRef
  • Obstructive jaundice of a parasitic etiology
    M.� Antonia Remacha ., M� Pilar Goñi , Jesus Espinel
    Revista Española de Enfermedades Digestivas.2018;[Epub]     CrossRef
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  • 77 Download
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  • 6 Crossref
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